| 中毒致死者体内芬氟拉明的GC/NPD,GC/MS法测定 |
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| 作者姓名： | Sun Y |
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| 作者单位： | 1. 司法部司法鉴定科学技术研究所,上海,200063
2. 华东政法学院,上海,200042 |
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| 摘 要： | 建立了生物检材中芬氟拉明的定性定量分析方法。体液及脏器组织经有机溶剂提取后 ,用GC/MS法进行药物筛选、定性 ,生物检材中的芬氟拉明浓度用4 -苯丁胺作内标、GC/NPD法测定。测得芬氟拉明中毒致死者的血液、尿液、肝等组织中浓度分别为7.8μg/ml、64.2μg/ml、31.3μg/g。并对尸体解剖所见及方法可行性进行讨论
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| 关 键 词： | 芬氟拉明 血 尿 GC/MS GC/NPD |
| 修稿时间： | 1999－03－03) |
Determination of fenfluramine in corpse using GC/NPD and GC/MS |
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| Sun Y.Determination of fenfluramine in corpse using GC/NPD and GC/MS[J].Journal of Forensic Medicine,2000,16(1):21-23. |
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| Authors: | Sun Y |
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| Institution: | Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063, P. R. China. |
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| Abstract: | A method was described for the determination of fenfluramine by GC/MS in blood, urine, liver, lung, kidney and heart tissues. After liquid-liquid extraction of fenfluramine in the specimens obtained from autopsy, the samples were qualitatively identified by GC/MS, and quantitatively determined by GC/NPD. 4-phenyl butylamine was used as internal standard. The concentrations of fenfluramine in blood, urine and liver were 7.8 micrograms/ml, 64.2 micrograms/ml and 31.3 micrograms/g respectively. The findings of autopsy and the results of toxicological analysis were also discussed. |
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| Keywords: | fenfluramine liquid-liquid extraction blood urine GC/MS GC/NPD |
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