| 白介素21的研究进展及其在寄生虫学上的应用 |
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| 引用本文： | 王燕,李佳缘,李中原,袁子国,朱兴全,黄思扬.白介素21的研究进展及其在寄生虫学上的应用[J].中国兽医科学,2012(4):431-434. |
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| 作者姓名： | 王燕 李佳缘 李中原 袁子国 朱兴全 黄思扬 |
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| 作者单位： | 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃省动物寄生虫病重点实验室;华南农业大学兽医学院 |
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| 基金项目： | 家畜疫病生物学国家重点实验室开放基金项目(SKLVEB2009KFKT014,SKLVEB2010KFKT010) |
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| 摘 要： | 白介素21(interleukin-21,IL-21)是近年来报道的一种新的细胞因子,主要由活化的CD4+T细胞、NK细胞和Th17细胞产生,其受体是Ⅰ型细胞因子受体家族成员之一,具有共同的γ链受体。IL-21与其受体结合后可调节B细胞的增殖,促进T细胞、NK细胞的增殖、分化并能提高NK细胞杀伤活性。全文介绍了IL-21的分子结构和生物学活性,阐述了IL-21在寄生虫感染中的作用,旨在为进一步研究IL-21在寄生虫学上的应用提供参考。
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| 关 键 词： | 白介素-21 生物学功能 寄生虫病 应用 |
Advance in interleukin-21 and its application to parasitology |
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| WANG Yan,LI Jia-yuan,LI Zhong-yuan,YUAN Zi-guo,ZHU Xing-quan,HUANG Si-yang.Advance in interleukin-21 and its application to parasitology[J].Veterinary Science in China,2012(4):431-434. |
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| Authors: | WANG Yan LI Jia-yuan LI Zhong-yuan YUAN Zi-guo ZHU Xing-quan HUANG Si-yang |
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| Institution: | 1(1.State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province/Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046, China;2.College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China) |
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| Abstract: | Interleukin-21(IL-21) is a recently discovered cytokine,which is mainly produced by the activation of CD4+T cells,NK cells and Th17 cells.The receptor of IL-21 is one of the members of the typeⅠ cell factor receptor family,among which there is a common gamma chain receptor.Once combined with its receptor,IL-21 can regulate proliferation of B cell,promote proliferation and differentiation of T cells and NK cells to enhance killing activity.This review summarized the molecular structure and biological activity of IL-21,and its expression during parasite infection to provide reference for further applications of IL-21. |
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| Keywords: | interleukin-21 biology function parasitic disease application |
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