| 广东汉族群体DXS6854基因座的多态性 |
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| 引用本文： | 刘秋玲,吕德坚,陆惠玲.广东汉族群体DXS6854基因座的多态性[J].中国法医学杂志,2002(Z1). |
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| 作者姓名： | 刘秋玲 吕德坚 陆惠玲 |
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| 作者单位： | 中山大学中山医学院法医学系，中山大学中山医学院法医学系，中山大学中山医学院法医学系 广东 广州 510089，广东 广州 510089，广东 广州 510089 |
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| 摘 要： | 目的调查X染色体特异性基因座DXS6854在广东汉族群体的多态性。方法利用PCR和聚丙烯酰胺凝胶电泳及银染法显色技术进行基因分型。结果在广东汉族189名无关女性个体及230名无关男性个体中,发现了8个等位基因。等位基因频率分布在0.0026—0.4522之间,女性的基因型分布符合Hardy—Weinberg平衡,女性和男性个体的个体识别率(DP)分别为0.8633和0.7012。三联体检验非父排除率(PE)为0.6712。结论DXS6854有较高的个体识别率和亲权排除率,在个人识别和女孩的亲权鉴定中有应用价值。
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| 关 键 词： | 法科学 等位基因频率 X染色体 多态性 |
Polymorphism of DXS6854 Locus in Guangdong Han Population |
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| LIU Qiuling,LU Dejian,LU Huiling/.Polymorphism of DXS6854 Locus in Guangdong Han Population[J].Chinese Journal of Forensic Medicine,2002(Z1). |
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| Authors: | LIU Qiuling LU Dejian LU Huiling/ |
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| Institution: | LIU Qiuling,LU Dejian,LU Huiling/Department of Forensic Biology,Zhongshan Medical College,Zhongshan University,Guangzhou 510089 |
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| Abstract: | Objective To investigate the polymorphism of DXS6854 locus in Guangdong Han population. Methods The DXS6854 locus was analyzed by PCR following polyacrylamide gel electrophoresis and silver staining. Results Among 189 females and 230 males from Guangdong Han population, 8 alleles were observed with frequencies ranging from 0.0026 to 0.4522. Exact tests demonstrated genotype frequencies in females had no departure from Hardy- Weinberg equilibrium. The discrimination powers for female and male original samples were 0.8633 and 0.7012, respectively. When both mother and her daughter were tested, the probability of excluding a random man as a father was 0.6712. Conclusion The DXS6854 locus is appropriate for individual identification and paternity testing involving a female child. |
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| Keywords: | Forensic science Allele frequency X- chromosome Polymorphism |
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