| DNA芯片分析单核苷酸多态性及其法医学应用 |
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| 作者姓名： | Bai P Tian L Zhou XP |
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| 作者单位： | 1. 四川大学华西基础医学与法医学院,四川,成都,610041
2. 苏州大学医学院法医教研室,江苏,苏州,215007 |
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| 摘 要： | DNA芯片技术作为一门新兴的高科技生物技术,显示了它旺盛的生命力和迅猛的发展势头。单核苷酸多态性(SingleNucleotidePolymorphisms,SNPs)是最常见的人类基因组变异类型。它作为一种有效的人类遗传标记,在疾病相关性研究、药物基因组学、法医学、人类进化和迁移等研究中发挥了重要作用。它同DNA芯片技术结合运用也将在法医检验,尤其是亲子鉴定和个人识别中发挥重要作用。本文主要讨论了DNA芯片和SNPs的特点,以及二者联合运用于法医学的价值。
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| 关 键 词： | DNA芯片 单核苷酸多态性 法医学 应用 |
| 文章编号： | 1004-5619(2005)02-0159-03 |
| 修稿时间： | 2004年9月12日 |
The joint applications of DNA chips and single nucleotide polymorphisms in forensic science |
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| Bai P,Tian L,Zhou XP.The joint applications of DNA chips and single nucleotide polymorphisms in forensic science[J].Journal of Forensic Medicine,2005,21(2):159-160,i001,i004. |
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| Authors: | Bai Peng Tian Li Zhou Xue-ping |
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| Institution: | College of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. bearbp@163.com |
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| Abstract: | DNA chip technology, being a new high-technology, shows its vigorous life and rapid growth. Single Nucleotide Polymorphisms (SNPs) is the most common diversity in the human genome. It provides suitable genetic markers which play a key role in disease linkage study,pharmacogenomics,forensic medicine,population evolution and immigration study. Their advantage such as being analyzed with DNA chips technology, is predicted to play an important role in the field of forensic medicine, especially in paternity test and individual identification. This report mainly reviews the characteristics of DNA chip and SNPs,and their joint applications in the practice of forensic medicine. |
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| Keywords: | DNA chip single nucleotide polymorphisms forensic medicine applications |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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