鲤醇硫酸酯钠急性中毒的实验病理研究

鲤醇硫酸酯钠（纯度99．2％），给小鼠腹腔注射，测得LD50为115．15mg／kg。40只小鼠随机分为4组，三个实验组分别以1．5LD50、1．0LD50和0．5LD50剂量腹腔注射染毒。结果表明，实验鼠肾小管上皮变性坏死；心肌细胞水变性，可见多发性肌溶灶；肝有单细胞性坏死。与草鱼胆汁中毒的病变基本相似。提示鲤醇硫酸酯钠是草鱼胆汁的主要毒性成分，主要损害肾，心肌，肝等脏器。

AN EXPERIMENTAL HISTO-PATHOLOGICAL STUDY MICE DIED OF ACUTE THE EXTRACT OF GRASS CARP BILE INTOXICATION (SODIUM CYPRINOL SULPHATE)

LD50 of 115. 15 mg/kg was determined by i. p injection of the extract of grass carp bile (99.2%of which is sodium cyprinol sulphate) into mice. Fourty mouse were dlvided randomly into 4 groups.Three experimental groups wers injected i. p. with 172. 73mg/kg, 115. 15mg/kg and 57.57mg/kg ofthe SCS respec-tively. The results showed the degeneration and necrosis of the epithelia of proximaland distaltubules;irregular fusion of foot processes of glomeruli; hydroplc degeneration and mutiplemyolysls of the cardiac muscles. The results lndicated that the rnain target organ were kidney,heartand liver. The histopathological change were similar to those occured in cases of the raw of grass carpbile poisonning. This experirnent suggests that the main toxic fraction of grass carp bile is sodiumcyprinol sulphatc.