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| 铜对生长猪肝中IGF-Ⅰ基因mRNA表达的影响 | |
| 引用本文： | 郑鑫,刘国文,杨连玉,李家奎,夏清娟,郝德威,王哲.铜对生长猪肝中IGF-Ⅰ基因mRNA表达的影响[J].中国兽医科学,2006,36(6):497-501. |
| 作者姓名： | 郑鑫 刘国文 杨连玉 李家奎 夏清娟 郝德威 王哲 |
| 作者单位： | 1. 吉林大学,畜牧兽医学院,吉林,长春,130026;吉林农业大学,动物科技学院,吉林,长春,130118 2. 吉林大学,畜牧兽医学院,吉林,长春,130026;内蒙古民族大学,动物科技学院,内蒙古,通辽,028042 3. 吉林大学,畜牧兽医学院,吉林,长春,130026;华中农业大学,动物科技学院,湖北,武汉,430070 4. 吉林农业大学,动物科技学院,吉林,长春,130118 5. 吉林大学,畜牧兽医学院,吉林,长春,130026 |
| 基金项目： | 国家高技术研究发展计划(863计划) |
| 摘 要： | 采用生长试验、免疫放射分析和定量PCR方法,观察了生长猪血液中类胰岛素生长因子(IGF-I)及其结合蛋白(IGFBP3)数量的变化和IGF-I基因在肝中表达量的变化。结果显示, 每1 kg饲料中添加125-250 mg铜,能够上调IGF-I基因的表达量,显著提高猪的平均日增重,促进生长猪循环血液中IGF-I浓度的增加。试验结果证实,铜是通过促进生长激素-胰岛素样生长因子轴相关因子的合成和分泌来发挥促生长作用的。 |
| 关 键 词： | 铜 猪 肝 类胰岛素生长因子 基因表达 |
| 文章编号： | 1673-4696(2006)06-0497-05 |
| 修稿时间： | 2005年12月6日 |
Effect of copper on insulin-like growth factor and gene expression of IGF- Ⅰ mRNA in liver of growing pigs |
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| ZHENG Xin,LIU Guo-wen,YANG Lian-yu,LI Jia-kui,XIA Qing-juan,HAO De-wei,WANG Zhe.Effect of copper on insulin-like growth factor and gene expression of IGF- Ⅰ mRNA in liver of growing pigs[J].Veterinary Science in China,2006,36(6):497-501. | |
| Authors: | ZHENG Xin LIU Guo-wen YANG Lian-yu LI Jia-kui XIA Qing-juan HAO De-wei WANG Zhe |
| Abstract: | The experiment was conducted in order to explore the effect of copper on growth correlation factor from the level of integer and gene expression, such as porcine liver IGF- I , in order to elucidate the modulation action of copper on liver and somatotropin axis correlation factor and internal mechanism of growth-promoting of copper. Quantitative changes of gene expression of IGF- I and IGFBP in blood were detected by growth promoting experiment,RIA and quantitative PCR. These results indicated that the addition of copper(125-250 mg/kg) in food improved the IGF- I gene expression, significantly increased the average body weight gain. These results indicated that copper stimulates growth by the synthesis and secretion of some factors of axis. |
| Keywords: | copper porcine liver insulin-like growth factor gene expression |
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