| COMT基因与精神分裂症患者暴力攻击行为关联性的研究进展 |
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| 引用本文： | 张钦廷,赵敏,谢斌.COMT基因与精神分裂症患者暴力攻击行为关联性的研究进展[J].法医学杂志,2014(3):197-201. |
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| 作者姓名： | 张钦廷 赵敏 谢斌 |
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| 作者单位： | 上海交通大学医学院附属精神卫生中心;司法部司法鉴定科学技术研究所上海市法医学重点实验室; |
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| 基金项目： | “十二五”国家科技支撑计划项目(2012BAK16B04);中央级公益性科研院所基本科研业务费专项基金(GY2014G-5);上海市法医学重点实验室(14DZ2270800) |
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| 摘 要： | 精神分裂症患者的暴力攻击行为发生率高于一般人群，暴力攻击行为在某些方面具有显著的遗传倾向性，与精神分裂症患者暴力攻击行为研究最多的是儿茶酚氧位甲基转移酶（catechol-O-methyltrans-ferase ， COMT ）基因。本文从COMT Val158Met 和COMT Ala72Ser 的SNP 多态性、COMT 基因单倍型、COMT基因启动子区DNA甲基化等方面对COMT基因变异与精神分裂症患者暴力攻击行为的相关性研究进行综述，并提出精神分裂症患者暴力攻击行为的遗传学研究方向。
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| 关 键 词： | 司法精神病学 精神分裂症 综述[文献类型] 儿茶酚氧位甲基转移酶 暴力 |
Progress on Association between COMT Gene and Violence Behavior in Patients with Schizophrenia |
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| ZHANG Qin-ting,ZHAO Min,XIE Bin.Progress on Association between COMT Gene and Violence Behavior in Patients with Schizophrenia[J].Journal of Forensic Medicine,2014(3):197-201. |
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| Authors: | ZHANG Qin-ting ZHAO Min XIE Bin |
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| Institution: | 1. Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, China; 2. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China) |
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| Abstract: | The prevalence of violence behavior in patients with schizophrenia is higher than that in common population. Data suggest that genetic factors may play a substantial role for the etiology of the behavior. Among the particular gene polymorphisms that have been considered to be involved in violence behavior, the catechol-O-methyltransferase （COMT） gene had been the focus of recent research. This article reviews the association research between COMT gene and violence behavior in patients with schizophrenia in several aspects： SNP polymorphism of COMT Val158Met and COMT Ala72Ser, haplotype of COMT gene and DNA methylation of promoter region of COMT gene. The genetic research direction is presented for patients with schizophrenia. |
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| Keywords: | forensic psychiatry schizophrenia review [publication type] catechol-O-methyltransferase violence |
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