| 线粒体DNA和端粒与年龄相关性的研究进展 |
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| 引用本文： | 徐晓玲,郑卫平,黄君键.线粒体DNA和端粒与年龄相关性的研究进展[J].中国法医学杂志,2005,20(6):347-349. |
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| 作者姓名： | 徐晓玲 郑卫平 黄君键 |
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| 作者单位： | 1. 北京人民警察学院,北京,102202
2. 军事医学科学院生物工程研究所,北京,100850 |
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| 摘 要： | 用DNA技术从分子水平上推断年龄,已成为法医学和人类学研究领域的新热点。目前用于年龄推断研究的DNA标记主要是线粒体和端粒。本文从线粒体DNA和端粒的概念、线粒体DNA的缺失和突变、端粒长度变化与年龄的相关性等方面对该领域的研究进展进行了综述。旨在为法医实践及进一步的研究提供新的方法和思路。
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| 关 键 词： | 法医物证学 线粒体DNA(mtDNA) 端粒 年龄推断 |
| 文章编号： | 1001-5728(2005)06-0347-03 |
| 修稿时间： | 2004年12月30 |
The development of research on correlation of mitochondrial DNA and telomere with individual age |
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| XU Xiao-ling,ZHENG We-ping,HUANG Jun-jian.The development of research on correlation of mitochondrial DNA and telomere with individual age[J].Chinese Journal of Forensic Medicine,2005,20(6):347-349. |
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| Authors: | XU Xiao-ling ZHENG We-ping HUANG Jun-jian |
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| Institution: | (XU Xiao-ling,ZHENG We-ping,HUANG Jun-jian.Beijing People Police college,Beijing 102202,China) |
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| Abstract: | Estimation of individual age using DNA molecular markers emerges as a new research hotspot in the forensic medicine and anthropology.Mitochondrial DNA(mtDNA)and telomere are the primary DNA markers used in deducing individual age in recent years.In this review,the correlation of mutation and deletion of mtDNA and telomere,and length of telomere with aging is discussed,which may provide a new method or idea for research and practice in forensic medicine. |
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| Keywords: | Forensic physical evidence Mitochondrial DNA(mtDNA) Telomere Age estimation |
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