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| 干生物基质点微样技术及其在法医毒物学中的应用 | |
| 引用本文： | 郭彩霞,严慧,刘伟,沈敏. 干生物基质点微样技术及其在法医毒物学中的应用[J]. 中国司法鉴定, 2021, 0(1): 29-38 |
| 作者姓名： | 郭彩霞 严慧 刘伟 沈敏 |
| 作者单位： | 司法鉴定科学研究院;中国药科大学药学院 |
| 基金项目： | 国家重点研发计划“科技冬奥”专项(2020YFF 0304505);上海市法医学重点实验室资助项目(17DZ2273200);上海市司法鉴定专业技术服务平台资助项目(19DZ2292700)。 |
| 摘 要： | 干生物基质点(Dried Matrix Spot,DMS)微样技术是通过将微量生物液体(如血液、尿液和唾液等)收集于卡纸上并干燥后形成的样本采集和储存形式.干生物基质点微样技术较传统的采样方法有明显的优势:取样量小,样品处理简单,储存运输方便,目前已应用于流行病学调查、毒药物监测、药代动力学研究和毒代动力学研究等领域.... |
| 关 键 词： | 干生物基质点 微样技术 法医毒物学 综述 |
The Dried Matrix Spot Micro-sampling Technique and its Application in Forensic Toxicology |
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| GUO Caixia,YAN Hui,LIU Wei,SHEN Min. The Dried Matrix Spot Micro-sampling Technique and its Application in Forensic Toxicology[J]. Chinese Journal of Forensic Sciences, 2021, 0(1): 29-38 | |
| Authors: | GUO Caixia YAN Hui LIU Wei SHEN Min |
| Affiliation: | (Shanghai Key Laboratory of Forensic Medicine,Shanghai Forensic Senice Platform,Key Lab of Forensic Science,Ministry of Justice,Academy of Forensic Science,Shanghai 200063,China;School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China) |
| Abstract: | The dried matrix spot(DMS)micro-sampling technique is a form of sample collection and storage,which is formed by the collection of trace biological liquid(such as blood,urine and saliva)on the card and the drying.Compared with the traditional sampling method,DMS micro-sampling technique has obvious advantages:small sample size,simple sample processing,convenient storage and transportation,it has been applied in the field of epidemiological investigation,toxicological monitoring,pharmacokinetics and toxicokinetics.In order to promote the development and application of DMS micro-sampling technology in forensic toxicology and the progress of identification technology,this paper reviewed the methods of sample collection,storage stability,sample processing and analysis of DMS. |
| Keywords: | dried matrix spot mMicro-sampling technique forensic toxicology review |
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