| PEG-碘海醇对比剂的家兔死后血管显影初探 |
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| 引用本文： | 王博,高艳斌,陈为龙,程志华,刘刚,张磊,周丹丹,王文馨,张勇,朱海超,唐明,赵露,王卓,白皛,张惠茅,王利君,陈志明.PEG-碘海醇对比剂的家兔死后血管显影初探[J].中国法医学杂志,2022(1):5-9. |
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| 作者姓名： | 王博 高艳斌 陈为龙 程志华 刘刚 张磊 周丹丹 王文馨 张勇 朱海超 唐明 赵露 王卓 白皛 张惠茅 王利君 陈志明 |
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| 作者单位： | 1.吉林大学基础医学院法医学系;2.吉林大学司法鉴定中心;3.长春市公安司法鉴定中心;4.吉林省公安厅物证中心 |
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| 摘 要： | 目的 为尸体血管造影剂组织外渗的评估建立一种动物模型.方法 配置不同浓度的碘海醇造影剂在体外进行CT扫描,选取ROI(S=100.0 mm2)并记录CT值;在家兔体内分别注射不同浓度的碘海醇造影剂后进行CT扫描,在主动脉弓内随机选取3个ROI(S=2.0 mm2)并记录CT值;在家兔体内分别注射不同浓度PEG+5％碘海...
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| 关 键 词： | 尸体血管造影 家兔 碘海醇 聚乙二醇 |
Study on the effects of polyethylene glycol on tissue extravasation of iohexol contrast agent in rabbits |
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| Wang Bo,Gao Yanbin,Chen Weilong,Cheng Zhihua,Liu Gang,Zhang lei,Zhou Dandan,Wang Wenxin,Zhang Yong,Zhu Haichao,Tang Ming,Zhao Lu,Wang Zhuo,Bai Xiao,Zhang Huimao,Wang Lijun,Chen Zhiming.Study on the effects of polyethylene glycol on tissue extravasation of iohexol contrast agent in rabbits[J].Chinese Journal of Forensic Medicine,2022(1):5-9. |
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| Authors: | Wang Bo Gao Yanbin Chen Weilong Cheng Zhihua Liu Gang Zhang lei Zhou Dandan Wang Wenxin Zhang Yong Zhu Haichao Tang Ming Zhao Lu Wang Zhuo Bai Xiao Zhang Huimao Wang Lijun Chen Zhiming |
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| Institution: | (Forensic Department of College of Basic Medical Science,Jilin University,Changchun 130021,China;Forensic Appraisal Center of Jilin University,Changchun 130021,China;Forensic Center of Changchun Public Security Bureaur,Changchun 130021,China;Evidence Identification Center of Jilin Province Public Security Bureau,Changchun 130051,China;Department of Vascular Surgery,The First Hospital of Jilin University,Changchun 130021,China;Department of Radiology,The First Hospital of Jilin University,Changchun 130021,China;Neiisoft of Medical Systems Co.,Ltd.,Shenyang 110167,China) |
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| Abstract: | Objective To establish an animal model for the evaluation of tissue extravasation of angiographic agents in cadavers.Methods Different concentrations of iohexol contrast agents were used in vitro CT scanning.ROI(S=100.0 mm2)was selected and CT value was recorded;After injecting different concentration of iohexol contrast agents in rabbits,CT scan was performed.Three ROIs(S=2.0 mm2)were randomly selected in the aortic arch and CT value was recorded;The mixture of contrast agent of PEG and 5% iohexol was injected into rabbits respectively,and then CT scan and 3 D reconstruction were performed.Results In vitro experiments confirmed that there was a positive correlation between iohexol and CT value in contrast agent(r=0.998);The concentration of iohexol contrast agent is positively correlated with the CT value of rabbit tissues(r=0.974);The addition of appropriate amount of PEG(≥60%)to the iohexol contrast agent can effectively reduce the leakage of the tissues around the gastrointestinal tract in rabbit cadaver.Conclusion The addition of appropriate amount of PEG(≥60%)to the iohexol contrast agent can effectively reduce the leakage of gastrointestinal tissues in cadaver.Rabbits could be an effective animal model for evaluating the leakage of tissues of contrast agents. |
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| Keywords: | Postmortem angiography Rabbit Iohexol Polyethylene glycol |
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