| 核酸及蛋白质在死亡时间推断中的应用 |
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| 作者姓名： | Li WC Zhang P Chen L |
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| 作者单位： | 复旦大学上海医学院法医学系; |
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| 摘 要： | 死亡时间(postmortem interval,PMI)推断一直是法医学研究的重点与难点.机体死亡后,组织细胞发生自溶,核酸等大分子物质发生降解,其中DNA含量呈逐渐下降趋势,与PMI具有一定的线性关系,管家基因β-actin、GAPDH mRNA具有一定的稳定性,也可作为内参照进行PMI推测.本文综述了目前DNA、...
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| 关 键 词： | 法医病理学 死亡时间 综述[文献类型] 核酸类 蛋白质类 |
Application of nucleic acids and proteins in estimation of postmortem interval |
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| Li WC,Zhang P,Chen L.Application of nucleic acids and proteins in estimation of postmortem interval[J].Journal of Forensic Medicine,2011,27(1):50-53. |
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| Authors: | Li Wen-can Zhang Ping Chen Long |
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| Institution: | LI Wen-can,ZHANG Ping,CHEN Long(Department of Forensic Medicine,Shanghai Medical College of Fudan University,Shanghai 200032,China) |
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| Abstract: | Accurate estimation of postmortem interval (PMI) is one of the most important and difficult issues in forensic medicine. After death, the tissues autolyze and biomacromolecules degrade. DNA concentration decreases gradually with linear relationship with PMI. The housekeeping gene mRNA, for example beta-actin, GAPDH, has certain stability and can be used to PMI estimation as internal standard. This paper reviews the research progress and problems about DNA, RNA and proteins in the estimation of PMI in order to provide guidance for forensic pathology. |
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| Keywords: | forensic pathology postmortem interval review[publication type] nucleic acids proteins |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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