脑源性神经营养因子与脊髓损伤

脊髓损伤(SCI)后,神经轴突具有一定再生能力,但需要有神经营养因子(NTFs)的参与。脑源性神经营养因子(BDNF)作为该家族中的一员,在脊髓神经元以及胶质细胞中均可合成,不仅具有神经元保护作用,还可以促进神经细胞的分化和再生,对SCI后机体功能的恢复起重要作用。进一步研究BDNF在SCI后的作用机制及其在SCI后的含量变化是否与损伤时间、损伤程度具有相关性,有可能为SCI的治疗和法医学损伤时间的推断提供新的方法。

Roles of brain-derived neurotrophic factor in spinal cord injury

Currently it is accepted that in mammals, neurons or axons possess regenerative potentials after spinal cord injury(SCI). However, it largely depends on participation of neurotrophic factors (NTFs). Brain-derived neurotrophic factor (BDNF) is one of the NTFs members, which is secreted by three major cell types in the spinal cord, namely, neurons, astrocytes and oligodendrocytes. BDNF can not only protect neurons, but also promote cell regeneration and differentiation. Further investigation on the roles that BDNF play in the SCI and the time-dependent pattern at the different posttraumatic intervals in SCI may offer a new way for the clinical treatment of SCI and the medico-legal wound age determination.