云南汉族NR3C1基因多态性与暴力攻击行为相关性

目的为了探讨云南汉族人群糖皮质激素受体基因(NR3C1)多态性与攻击行为的相关性。方法应用改良多重高温连接酶反应(improve multiplex ligasedetection reaction,iMLDR)技术检测194例云南汉族有攻击行为的监狱服刑人员和301例健康对照样本的NR3C1基因SNPs(rs6190、rs6191、rs6198、rs41423247、rs56149945)基因型,采用SPSS19.0软件、PHASE2.1平台进行统计学分析。结果 rs6191和rs41423247单个基因座的等位基因分布在非攻击组与攻击组、抢劫亚组和故意伤害亚组中均无显著性差异;rs41423247的基因型在非攻击组与抢劫亚组中的分布有显著性差异(p=0.048);构建的4种单倍型分布在非攻击组与攻击组、抢劫亚组和故意伤害亚组中均无显著性差异。结论云南汉族人群NR3C1基因的rs41423247基因座的单基因座多态性可能与指向他人的躯体攻击行为相关,rs6191基因座的单基因座多态性可能与暴力攻击行为无关。

The relevancebetween genetic polymorphismof NR3C1andaggressive behavior in Yunnan Han population

Objective To study the correlation between the polymorphisms of NR3C1 gene and aggressive behavior in Yunnan Han population.Methods Five SNPs of the NR3C1 gene (rs6190,rs6191,rs6198,rs41423247 and rs56149945) were genotyped in 194 unrelated prisoners who committed violent-crimes and 301 healthy controls using improved Multiplex-ligase-detection reaction(iMLDR) method,and the data were statistically analyzed with the SPSS19.0soflware and PHASE2.1platform.Results Single locus analysis showed that the allelic distribution of rs6191and rs41423247did not show significant differencesbetween the control groupand the aggressive-behavior group as well as the robbery sub-group and intentional injury sub-group.However,significant difference was foundin the rs41423247 genotype distribution betweencontrol groupand robbery sub-group (p=0.048).In addition,there were no significant differences for the four haplotypes between the control group,the attack group,the robbery subgroup and the intentional injury subgroup.Conclusion These findings indicate that rs41423247 polymorphism of the NR3C1gene might play a role in susceptibility to aggressive behavior and rs6191 polymorphismmay not be correlated withaggressive behavior.