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Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports
Authors:Marques E P,Gil F,Proen"  ca P,Monsanto P,Oliveira M F,Castanheira A,Vieira D N
Affiliation:Laborat?orio de Toxicologia Forense, Instituto de Medicina Legal de Coimbra, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal. imltoxic@ci.uc.pt
Abstract:
This paper describes an analytical method for strychnine determination in biological samples by gas chromatography/mass spectrometry and their application in the investigation of two cases involving strychnine ingestion: A fatal case and a clinical one. The strychnine is isolated from biological samples using a liquid-liquid extraction procedure. The clean-up procedure is performed using an acid solution. Papaverine is used as internal standard in the quantification of strychnine. In the analysed specimens, the limits of quantification were 0.1 microg/ml or 0.1 microg/g. The recovery rate ranged from 75.0% to 98.7% and the coefficients of variation ranged from 4.8% to 10.5%.
Keywords:
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