芪贞降糖颗粒治疗糖尿病自主神经病变30例

目的 观察芪贞降糖颗粒治疗糖尿病自主神经病变（diabetic autonomic neuropathy DAN）的临床疗效。方法 将60例DAN患者随机分为对照组（30例）和治疗组（30例）。在糖尿病基础治疗的基础上，对照组口服甲钴胺，治疗组加用芪贞降糖颗粒口服。连续治疗3个月后，观察并比较两组DAN疗效、单个中医症状疗效及足汗腺神经受损风险的改善情况。结果 治疗组的DAN疗效显著优于对照组（P＜0.05），总有效率显著高于对照组（P＜0.05）；治疗组在改善倦怠乏力、口干咽燥、口渴喜饮、气短懒言、自汗盗汗方面显著优于对照组（P<0.05）；治疗组在降低足汗腺神经受损风险方面显著优于对照组（P<0.01）。结论 芪贞降糖颗粒可以明显改善DAN患者泌汗运动神经功能和DAN相关症状。

Clinical Efficacy of Qizhen Jiangtang Granules in Treatment of Diabetic Autonomic Neuropathy: A Report of 30 Cases

Objective To observe the clinical efficacy of Qizhen Jiangtang Granules in the treatment of diabetic autonomic neuropathy (DAN). Methods Sixty DAN patients were randomly divided into control group (n=30) and treatment group (n=30). In addition to the basic treatment, the control group received oral mecobalamin, while the treatment group received oral Qizhen Jiangtang Granules. The course of treatment was 3 months for both groups. The two groups were compared in terms of DAN outcome, the outcome of each traditional Chinese medicine symptom, and the reduction in risk of damage of sweat gland nerve of the foot. Results The treatment group had a significantly better DAN outcome (P<0.05) and a significantly higher overall response rate (P<0.05), as compared with the control group. In addition, the treatment group was superior to the control group in terms of the improvements in fatigue and weakness, dry mouth and throat, thirst with liking for fluids, short breath and laziness to speak, and spontaneous sweating and night sweating (P<0.05) and the reduction in the risk of damage of sweat gland nerve of the foot (P<0.01). Conclusion Qizhen Jiangtang Granules can significantly improve sudomotor function and relieve DAN-related symptoms in DAN patients.