桑白皮汤加减对痰热郁肺型慢性阻塞性肺疾病急性加重期炎性指标的影响

目的 观察桑白皮汤加减治疗痰热郁肺型慢性阻塞性肺疾病急性加重期的临床疗效及其对炎性指标的影响。方法 将60例痰热郁肺型慢性阻塞性肺疾病急性加重期患者，按照随机对照试验研究设计方法随机分为两组，每组30例。对照组为常规西医治疗；治疗组在常规西医治疗基础上，加用桑白皮汤口服，疗程均为10 d。比较治疗前后两组中医证候积分、血C-反应蛋白（c-reactive protein，CRP）、降钙素原（procalcitonin，PCT）水平以及临床疗效。结果 两组患者治疗后中医证候积分均较治疗前下降，差异具有统计学意义（P＜0.05），且治疗组明显低于对照组（P＜0.05）；治疗后两组患者血CRP、PCT水平均较治疗前改善，差异具有统计学意义（P＜0.05），治疗组血CRP改善幅度优于对照组（P<0.05）；治疗组临床疗效优于对照组，差异具有统计学意义（P＜0.05）。结论 桑白皮汤配合常规西药治疗痰热郁肺型慢性阻塞性肺疾病急性加重期，可明显改善患者临床症状及降低血CRP、PCT含量，较单纯西医治疗具有更好的临床疗效。

Effect of Modified Sangbaipi Decoction on Inflammatory Indices for Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Phlegm-heat Obstructing the Lungs

Objective To investigate the clinical efficacy of modified Sangbaipi Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with phlegm-heat obstructing the lungs and its effect on inflammatory indices. Methods A total of 60 AECOPD patients with phlegm-heat obstructing the lungs were randomly divided into two groups with 30 patients in each group according to the design of a randomized controlled trial. The patients in the control group were given conventional Western medicine treatment, and those in the control group were given oral Sangbaipi Decoction in addition to the conventional Western medicine treatment. The course of treatment was 10 days for both groups. The traditional Chinese medicine (TCM) syndrome score, serum levels of C-reactive protein (CRP) and procalcitonin (PCT), and clinical outcome were compared between the two groups. Results Both groups had significant reductions in the TCM syndrome score after treatment (P<0.05), and the treatment group had a significantly lower score than the control group (P<0.05). Both groups had significant improvements in the serum levels of CRP and PCT after treatment (P<0.05), and the treatment group had a significantly better improvement in the serum level of CRP compared with the control group (P<0.05). The treatment group had a significantly better clinical outcome than the control group (P<0.05). Conclusion In the treatment of AECOPD with phlegm-heat obstructing the lungs, Sangbaipi Decoction combined with conventional Western medicine treatment can significantly improve patients'' clinical symptoms and reduce the serum levels of CRP and PCT and has a better clinical effect than Western medicine treatment alone.