消瘀接骨散联合运动训练治疗气滞血瘀型 膝骨关节炎疗效观察

目的 观察消瘀接骨散和运动训练联合治疗对气滞血瘀型膝骨关节炎（knee osteoarthritis，KOA）的临床疗效。方法 将62例KOA患者随机分为研究组和对照组，每组31例。两组患者治疗期间均口服氨基葡萄糖，对照组另行患膝股四头肌运动训练，研究组在行患膝股四头肌运动训练的同时外敷消瘀接骨散，治疗周期为2周。分别观察和比较3个时间点（治疗前、治疗后2周和随访第6周）两组患者疼痛视觉模拟量表（visual analogue scale，VAS）评分、西安大略和麦克马斯特大学骨关节炎指数（Western Ontario and McMaster Universities Osteoarthritis Index，WOMAC）,观察两组临床疗效。结果 与治疗前比较，治疗2周后、随访第6周两组VAS评分、WOMAC总评分均明显减少（P<0.05）。两组治疗2周后VAS评分、WOMAC总评分比较，差异均有统计学意义（P<0.05）。随访第6周两组VAS评分比较，差异无统计学意义（P＞0.05）；WOMAC总评分比较，差异有统计学意义（P<0.05）。两组临床疗效分布比较，差异有统计学意义（P<0.05）。结论 消瘀接骨散结合运动训练对KOA的疼痛及关节功能障碍疗效确切。

Clinical Effect of Xiaoyu Jiegu Powder Combined with Exercise Training in Treatment of Knee Osteoarthritis with Qi Stagnation and Blood Stasis

Objective To investigate the clinical effect of Xiaoyu Jiegu Powder combined with exercise training in the treatment of knee osteoarthritis (KOA) with qi stagnation and blood stasis.Methods A total of 62 patients with KOA were enrolled and randomly divided into study group and control group, with 31 patients in each group. The patients in the control group were given oral glucosamine combined with the training of the quadriceps femoris of the affected knee, and those in the study group were given external application of Xiaoyu Jiegu Powder in addition to the treatment in the control group. The course of treatment was 2 weeks for both groups. The two groups were compared in terms of clinical outcome and Visual Analogue Scale (VAS) score and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) before treatment, after 2 weeks of treatment, and at week 6 of follow up.Results Both groups had significant reductions in VAS score and WOMAC after 2 weeks of treatment and at week 6 of follow up(P<0.05),and after 2 weeks of treatment, there were significant differences in VAS score and WOMAC between the two groups(P<0.05).At week 6 of follow up, there was no significant difference in VAS score between the two groups(P>0.05),while there was a significant difference in WOMAC between the two groups(P<0.05).There was a significant difference in the distribution of clinical outcomes between the two groups(P<0.05).Conclusion Xiaoyu Jiegu Powder combined with exercise training has a good clinical effect in improving pain and joint dysfunction of KOA.