痰热清联合抗生素治疗食管癌术后早期重症肺炎的临床疗效

目的 评价痰热清联合抗生素治疗食管癌术后早期重症肺炎的临床疗效。方法 将52例食管癌术后早期重症肺炎患者随机分为对照组（26例）及治疗组（26例），对照组给予抗生素、营养支持、对症处理等基础治疗，治疗组在对照组的基础上加用痰热清注射液治疗；观察两组患者治疗前、治疗第7天、第14天时白细胞（white blood cell，WBC）、C反应蛋白（C-reactive protein，CRP）、降钙素原（procalcitonin，PCT）水平，两组患者的机械通气时间、重症监护室（intensive care unit，ICU）住院天数、第14天的治疗有效率、第28天死亡率及并发症发生率。结果 两组患者治疗后第7天和第14天，WBC、CRP、PCT均较治疗前明显下降（P<0.05）；治疗组WBC、CRP、PCT与对照组比较，差异具有统计学意义（P<0.05）。治疗组患者机械通气时间及ICU住院时间明显少于对照组，差异具有统计学意义（P<0.05）。治疗组总有效率明显高于对照组（P<0.05），第28天的死亡率明显小于对照组（P<0.05）；两组患者的并发症发生率比较，差异无统计学意义（P>0.05）。结论 痰热清联合抗生素治疗食管癌术后早期肺部感染疗效显著，能显著缩短病程，改善预后。

Clinical Effect of Tanreqing Combined with Antibiotics in Treatment of Severe Pneumonia Early after Surgery for Esophageal Cancer

Objective To investigate the clinical effect of Tanreqing in the treatment of patients developing severe pneumonia early after surgery for esophageal cancer. Methods A total of 52 patients who developed severe pneumonia early after surgery for esophageal cancer and were admitted to our hospital were enrolled and randomly divided into control group and treatment group, with 26 patients in each group. The patients in the control group were given basic treatment including antibiotics, nutritional support, and symptomatic treatment, and those in the treatment group were given Tanreqing injection in addition to the treatment in the control group. The two groups were observed with respect to white blood cell count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) before treatment and at 7 and 14 days after treatment, duration of mechanical ventilation, length of stay in the intensive care unit (ICU), response rate at 14 days after treatment, mortality rate at 28 days after treatment, and incidence rate of complications. Results At 7 and 14 days after treatment, both groups had significant reductions in WBC, CRP, and PCT (P<0.05), and there were significant differences in WBC, CRP, and PCT between the two groups (P<0.05). The treatment group had significantly shorter duration of mechanical ventilation and length of stay in the ICU than the control group (P<0.05). Compared with the control group, the treatment group had a significantly higher overall response rate and a significantly lower mortality rate at 28 days after treatment (P<0.05), and there was no significant difference in the incidence rate of complications between the two groups (P>0.05). Conclusion Tanreqing combined with antibiotics has a marked clinical effect in the treatment of pulmonary infection early after thoracotomy for esophageal cancer and can significantly shorten the course of disease and improve prognosis.