中医药干预86例进展期胃癌的生存分析

目的探讨进展期胃癌中医药干预现状与生存期的相关性。方法回顾性研究安徽医科大学第一附属医院中西医结合肿瘤科、安徽省立医院中医肿瘤科收治的86例进展期胃癌患者的临床资料,统计中医药干预起点、干预时间、干预策略以及患者的1、3年生存率,对患者信息进行单因素、多因素分析,筛选出影响进展期胃癌患者预后的因素。结果86例进展期胃癌患者1、3年生存率分别为90.7%、48.8%。单因素分析显示,TNM分期、肿瘤分化程度、根治手术、足疗程化学治疗、中医证型、中医药干预起点及中医药干预持续时间对生存期的影响具有统计学意义(P<0.05)。多因素分析显示,TNM分期、根治手术、足疗程化学治疗、中医药干预持续时间对生存期的影响均具有统计学意义(P<0.05)。结论根治性手术治疗及足疗程化学治疗是延长进展期胃癌患者生存期的重要手段;TNM分期是影响患者预后的危险因素;进展期胃癌中医证型以脾胃虚寒型最为多见;中医药干预持续时间与患者生存期呈正相关。

Survival of Patients with Advanced Gastric Carcinoma Receiving Traditional Chinese Medicine Intervention: An Analysis of 86 Cases

Objective To investigate the association between traditional Chinese medicine (TCM) intervention and survival time in patients with advanced gastric carcinoma. Methods A retrospective analysis was performed for the clinical data of 86 patients with advanced gastric carcinoma who were admitted to Department of Integrated Traditional Chinese and Western Medicine Oncology, The First Affiliated Hospital of Anhui Medical University and Department of TCM Oncology, Anhui Provincial Hospital, and a statistical analysis was performed for the starting point of TCM intervention,duration of TCM intervention,intervention strategies,and 1- and 3-year survival rates.Univariate and multivariate analyses were performed for patient information to screen out the influencing factors for the prognosis of patients with advanced gastric carcinoma. Results For the 86 patients with advanced gastric carcinoma, the 1- and 3-year survival rates were 90.7% and 48.8%, respectively. The univariate analysis showed that TNM stage, degree of tumor differentiation, radical treatment, full-course chemotherapy, TCM syndrome type, starting point of TCM intervention, and duration of TCM intervention had significant influence on survival time (P<0.05). The multivariate analysis showed that TNM stage, radical treatment, full-course chemotherapy, and duration of TCM intervention had significant influence on survival time (P<0.05). Conclusion Radical surgery and full-course chemotherapy are important methods to prolong the survival time of patients with advanced gastric carcinoma. TNM stage is a risk factor for the prognosis of patients. Deficient cold of spleen and stomach is the most common TCM syndrome type in patients with advanced gastric carcinoma. Duration of TCM intervention is positively correlated with survival time.