| Caspase与皮肤损伤 |
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| 引用本文： | 杜宇,官大威,赵锐.Caspase与皮肤损伤[J].中国法医学杂志,2005,20(2):92-94. |
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| 作者姓名： | 杜宇 官大威 赵锐 |
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| 作者单位： | 1. 中国医科大学法医学院,辽宁,沈阳,110001;中国刑警学院法医学系,辽宁,沈阳,110035
2. 中国医科大学法医学院,辽宁,沈阳,110001 |
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| 基金项目： | 国家自然科学基金项目(30271347)，教育部留学归国基金资助项目(2002-367) |
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| 摘 要： | Caspase家族,目前已知至少由14个成员组成,该家族成员在细胞凋亡过程中发挥着重要作用。实验研究表明,在皮肤损伤及愈合过程中,伴随着Caspase的活化和表达,这可能与Caspase诱导细胞凋亡的发生有关。深入研究Caspase在皮肤损伤及愈合过程中的作用机制,有望为皮肤损伤的治疗和法医学损伤时间的推断提供新的方法。本文综述了Caspase家族的生物学特性以及Caspase在皮肤损伤及愈合过程中的研究进展,认为Caspase在皮肤损伤及愈合过程中发挥重要作用,具有深入研究的必要。
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| 关 键 词： | 法医病理学 Caspase 皮肤 损伤愈合 |
| 文章编号： | 1001-5728(2005)02-0092-03 |
| 修稿时间： | 2003年12月1日 |
Caspases and skin wound healing |
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| DU Yu,GUAN Da-wei,ZHAO Rui.Caspases and skin wound healing[J].Chinese Journal of Forensic Medicine,2005,20(2):92-94. |
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| Authors: | DU Yu GUAN Da-wei ZHAO Rui |
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| Abstract: | Hitherto, it is reported that caspase family includes 14 members at least, which play important roles in executing cell apoptosis. Experimental studies have proved that caspases are expressed and activated in the injured skin and during skin wound healing, which suggests that cell apoptosis induced by caspases may occur. Further investigation on the roles that caspases play in the injured skin and during skin wound healing may offer a new way for the clinical treatment of the skin wound and the medico-legal wound age determination. The article reviews the biologic characters of caspases and the advances in the studies on the caspases in the skin wound and wound healing. It is suggested that caspases exert significant parts during skin wound healing, which are worthy of further investigation. |
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| Keywords: | Forensic pathology Caspase Skin Wound healing $$ |
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