| 中国北方汉族人群HLA-DQα基因型及其等位基因频率的分布 |
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| 引用本文： | 姜先华,吕世惠,阎威,王军,和中年,朱郁文,王国林,韩景松,魏平.中国北方汉族人群HLA-DQα基因型及其等位基因频率的分布[J].中国法医学杂志,1995(1). |
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| 作者姓名： | 姜先华 吕世惠 阎威 王军 和中年 朱郁文 王国林 韩景松 魏平 |
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| 作者单位： | 辽宁省刑事科学技术研究所!沈阳，110032，辽宁省刑事科学技术研究所!沈阳，110032，辽宁省刑事科学技术研究所!沈阳，110032，辽宁省刑事科学技术研究所!沈阳，110032，辽宁省刑事科学技术研究所!沈阳，110032，辽宁省刑事科学技术研究所!沈阳，110032，辽宁省刑事科学技术研究所!沈阳，110 |
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| 摘 要： | 应用PCR和等位基因特异性寡该苷酸（ASO）探针杂交技术对中国北方汉族人群的HLA－DQα基因进行分型。在246例无关个体中观察到4种等位基因组成的10种基因型。等位基因频率分布在10．0～31．9％之间。基因型的分布符合Hardy－Weinberg定律。DP值为0．8669。对6个家系49个个体的调查表明，HLA－DQα基因按孟德尔方式遗传。不同人群HLA－DQα的DP值比较，中国人群高于其它人群。
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| 关 键 词： | HLA－DQα基因 聚合酶链式反应（PCR） 等位基因特异性寡核苷酸（ASO） 群体遗传学 |
A STUDY ON THE DISTRIBUTION OF THE HLA-DQα ALLELE AND GENOTYPE IN NORTHERN CHINESE HAN POPULATION |
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| Jiang Xianhua,et al.A STUDY ON THE DISTRIBUTION OF THE HLA-DQα ALLELE AND GENOTYPE IN NORTHERN CHINESE HAN POPULATION[J].Chinese Journal of Forensic Medicine,1995(1). |
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| Authors: | Jiang Xianhua |
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| Abstract: | In this paper, the polymerase chain reaction(PCR) and allele sedic oligonucleoide (ASO) hybridization were employed to detect frequencies of the HLA-DQα alleles and genotypes of the northern Chinese Han population. Ten genotypes determined by four alleles of HLA-DQα lori were observed among 246 unrelated individuals with allele frequencies ranging from 10. 0% to 39. 1 %. The distribution of the observed genotypes is in Hardy-Weinberg equilibrium. The discrimnating power(DP) of this system in 0. 8669. A study of six families having 49 individuals demonstrated that the inheritance of the HLA-DQα genes is in Mendelian fashion. Additionally, the data of this study was compared with the results of the PCR-ASO-based genotyping of HLA-DQα loci of various populations which had been reported previously. |
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| Keywords: | HLA-DQα Polymerase chain reaction Allele specific oligonucleotide Population genetcs |
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