An unusual case of identification by DNA analysis of siblings |
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Authors: | Franz Neuhuber Max P Baur Jan Cemper-KiesslichBettina Dunkelmann Fabio Monticelli |
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Institution: | a Institute of Legal Medicine, University of Salzburg, Ignaz-Harrer-Str. 79, A-5020, Austria b Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany |
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Abstract: | A badly decomposed body required identification by means of DNA analysis. A brother and sister of the deceased were available as reference subjects. Although investigation of Y-chromosomal markers established an exclusion condition, autosomal markers suggested a positive identification. In order to increase the reliability of the tests, X-chromosomal markers were also investigated. This analysis showed the body to have an XXY genotype (Klinefelter's syndrome). A number of hypotheses were assessed using biostatistical methods, ultimately resulting in a definite identification. The special aspect of Klinefelter's syndrome proved highly useful for biostatistical analysis. |
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Keywords: | Forensic identification Klinefelter syndrome Biostatistics Complex pedigree analysis |
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