| PDGFR-β在大鼠闭合性脑损伤中的表达 |
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| 引用本文： | 廖志钢,李雷波,陈晓刚,黄培军,易旭夫,张林,王世春.PDGFR-β在大鼠闭合性脑损伤中的表达[J].中国法医学杂志,2004,19(3):131-133. |
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| 作者姓名： | 廖志钢 李雷波 陈晓刚 黄培军 易旭夫 张林 王世春 |
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| 作者单位： | 1. 四川大学华西基础医学与法医学院法医病理教研室,四川,成都,610041
2. 济南市公安局刑警支队法医室,山东,济南,250002 |
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| 基金项目： | 教育部博士点专项基金(0610032) |
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| 摘 要： | 目的 观察液压冲击脑损伤后血小板衍生生长因子受体(PDGFR-β)的表达变化。方法 复制大鼠闭合性脑损伤模型,应用免疫组化和图像分析技术观察并分析大鼠脑损伤后不同时间PDGFR-β的表达情况。结果 脑损伤后1h即见PDGFR-β的表达上调,于4d达到高峰,14d时接近但仍高于对照组。结论 液压冲击脑损伤后PDGFR-β表达上调及其变化,与脑损伤后经过时间有关。
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| 关 键 词： | 法医病理学 免疫组织化学 图像分析技术 闭合性脑损伤 血小板衍生生长因子受体(PDGFR-β) |
| 文章编号： | 1001-5728(2004)03-0131-03 |
| 修稿时间： | 2003年7月1日 |
Expression of PDGFR-β in rats suffering from closed brain injury |
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| Institution: | (LIAO Zhi-gang,LI Lei-bo,CHEN Xiao-gang,et al. / Forensic Pathology Department,School of Legal Medicine,Sichuan University,Chengdu 610041,China) |
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| Abstract: | Objective To elucidate the changes of PDGFR-β in the rat brain injured by a hydro-percussion device. Methods The expression of PDGFR-β protein was studied by immunohistochemistry and image analysis system. Results A gradually enhanced expression of PDGFR-β protein was observed in inju-ried rat brain since 1h to 4d peak. After that, the protein expression decreased but remained above control levels till 14d. Conclusion Hydro-percussion brain injury induced expression of PDGFR-β. The regular rise of PDGFR-β level in time course seems to be of value in estimating the age of brain injury. |
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| Keywords: | Forensic pathology Immunohistochemistry Image analysis system Hydro-percussion brain injury PDGFR-β |
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