| PTEN在冠心病心肌组织中的表达 |
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| 引用本文： | 李雪榕,何勇,雷雨佳,覃西河,韦庆涛,潘新民,李立娟,张林.PTEN在冠心病心肌组织中的表达[J].法医学杂志,2016(2). |
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| 作者姓名： | 李雪榕 何勇 雷雨佳 覃西河 韦庆涛 潘新民 李立娟 张林 |
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| 作者单位： | 1. 四川大学华西基础医学与法医学院,四川 成都,610041;2. 河南科技大学法医学院,河南 洛阳,471003 |
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| 摘 要： | 目的观察冠状动脉粥样硬化性心脏病(冠心病)患者心肌组织中人第10号染色体缺失的磷酸酶与张力蛋白同源基因(phosphatase and tensin homology deleted on chromosome ten,PTEN)的表达,探讨PTEN的表达与冠心病发生发展的相关性。方法选取经病理学确诊为冠心病死亡案例16例作为冠心病组,非心肌病变死亡案例19例作为对照组,采用免疫组织化学以及实时荧光定量PCR法检测心肌组织中PTEN蛋白及其m RNA的表达。结果冠心病组PTEN蛋白的表达量低于对照组(P0.05);与对照组相比,冠心病组PTEN m RNA表达的差异无统计学意义(P0.05)。结论 PTEN可能与冠心病的发生发展有关。
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| 关 键 词： | 法医病理学 冠状动脉硬化 心肌 人第10号染色体缺失的磷酸酶与张力蛋白同源基因 |
Expression of PTEN in Myocardial Tissue in Coronary Heart Disease |
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| Abstract: | Objective To observe the expression of phosphatase and tensin hom ology deleted on chrom o-som e ten (PTEN) in m yocardial tissue in patients w ith coronary heart disease, and explore the relevance betw een the expression of PTEN and the occurrence and developm ent of coronary heart disease. Methods A total of 16 death cases w ith pathological diagnosis of coronary heart disease w ere collected as experi-m ental group, and 19 cases w ithout m yocardial lesions w ere selected as control group. The expression of PTENprotein and its m RNA w ere detected by im m unohistochem istry and real-tim e fluorescence quanti-tative PC R respectively. The correlation betw een the expression of PTEN and the pathogenesis of coronary heart disease w as analyzed. Results The expression of PTENprotein in myocardium in cases w ith coro-nary heart disease w as significantly low er com pared w ith the control group (P<0.05). There w as no sta-tistical difference of the expression of PTEN m RNA betw een experim ental and control group (P>0.05). Conclusion PTEN m ay be involved in the occurrence and developm ent of coronary heart disease. |
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| Keywords: | forensic pathology coronary arteriosclerosis m yocardium phosphatase and tensin hom olog deleted on chrom osom e ten |
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