Raman Spectroscopic Differences between Ephedrine and Pseudoephedrine |
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| Authors: | Tianmin Shu MS Xing Yang PhD Wenbo Li MS Xiaojun Yao PhD |
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| Institution: | 1. Department of Criminal Investigation, The Third Research Institute of the Ministry of Public Security, No. 76, Yueyang Road, Xuhui District, Shanghai, China, 200031;2. College of Chemistry and Chemical Engineering, Lanzhou University, No. 222, South Tianshui Road, Chengguan District, Lanzhou, Gansu Province, China, 730000;3. College of Chemistry and Chemical Engineering, Lanzhou University, No. 222, South Tianshui Road, Chengguan District, Lanzhou, Gansu Province, China, 730000Corresponding author: Xiaojun Yao, Ph.D. E‐mail: . |
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| Abstract: | Ephedrine (EPH) and pseudoephedrine (PSE) were studied by micro‐Raman spectroscopy and UV resonance Raman spectroscopy excited at 785 and 360 nm, respectively. Raman bands at approximately 245 and 410 cm?1 for ephedrine have apparent differences from the same bands at approximately 215, 265, 350, 450, and 555 cm?1 for pseudoephedrine, and these differences can be applied to distinguish between EPH and PSE. Additionally, density functional theory was used for the Raman calculations to obtain results identical to the experimental spectra. This work is expected to expand the applications of Raman spectroscopy in forensic science. |
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| Keywords: | forensic science ephedrine pseudoephedrine Raman spectroscopy distinction density functional theory |
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