| 重组鸡白细胞介素6对不同种类疫苗的免疫增强作用 |
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| 引用本文： | 闫若潜,谢彩华,吴志明,李桂喜,张志凌,张健,刘梅芬.重组鸡白细胞介素6对不同种类疫苗的免疫增强作用[J].中国兽医科学,2010,40(5). |
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| 作者姓名： | 闫若潜 谢彩华 吴志明 李桂喜 张志凌 张健 刘梅芬 |
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| 作者单位： | 闫若潜,谢彩华,吴志明,张志凌,张健,刘梅芬,YAN Ruo-qian,XIE Cai-hua,WU Zhi-ming,ZHANG Zhi-ling,ZHANG Jian,LIU Mei-fen(河南省动物疫病预防控制中心,河南,郑州,450008);李桂喜,LI Gui-xi(商丘市动物疫病预防控制中心,河南,商丘,476000) |
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| 基金项目： | 河南省科技攻关计划项目 |
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| 摘 要： | 为评价重组鸡白细胞介素6(rChIL-6)在商品鸡体内对不同种类疫苗的免疫增强作用,采用不同接种方式,应用rChIL-6分别对不同种类新城疫病毒(NDV)单联疫苗和新城疫病毒-传染性支气管炎病毒-禽流感病毒H9亚型三联疫苗(NDV-IBV-H9)进行了免疫增强试验以及传染性法氏囊病病毒(IBDV)单联油乳剂灭活疫苗的免疫增强田间试验,并进行了将rChIL-6与NDV Ⅳ系预混合乳化制备成的灭活疫苗的免疫试验.结果表明,将rChIL-6与NDVⅣ系、Ⅰ系活疫苗预混合后分别采用滴鼻点眼、肌肉注射接种方式的免疫增强效果优于其他方式;rChIL-6与NDV抗原预混后制备成油乳剂灭活疫苗的免疫增强效果优于将相同抗原量的NDV油乳剂灭活疫苗和rChIL-6同时分点免疫接种.rChIL-6对NDV油乳剂灭活疫苗的免疫增强效果优于活疫苗,对NDV单联灭活疫苗的免疫增强效果优于NDV-IBV-H9三联灭活疫苗.田间试验表明,rChIL-6对IBDV油乳剂灭活疫苗首免和二免都具有显著的免疫增强作用,二免的免疫增强效果优于首免.这些研究结果为进一步开展新型鸡基因工程免疫增强剂研究奠定了基础.
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| 关 键 词： | 鸡 重组鸡白细胞介素6 疫苗 免疫增强作用 新城疫 传染性法氏囊病 禽流感H9N2亚型 |
Immunopotentiation effect of the recombinant chicken interleukin-6 on different kinds of vaccines |
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| YAN Ruo-qian,XIE Cai-hua,WU Zhi-ming,LI Gui-xi,ZHANG Zhi-ling,ZHANG Jian,LIU Mei-fen.Immunopotentiation effect of the recombinant chicken interleukin-6 on different kinds of vaccines[J].Veterinary Science in China,2010,40(5). |
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| Authors: | YAN Ruo-qian XIE Cai-hua WU Zhi-ming LI Gui-xi ZHANG Zhi-ling ZHANG Jian LIU Mei-fen |
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| Institution: | YAN Ruo-qian1,XIE Cai-hua1,WU Zhi-ming1,LI Gui-xi2,ZHANG Zhi-ling1,ZHANG Jian1,LIU Mei-fen1 (1.Henan Centre for Animal Diseases Control , Prevention,Zhengzhou 450008,China,2.Shangqiu Centre for Animal Diseases Control , Prevention,Shangqiu 476000,China) |
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| Abstract: | To evaluate the immunopotentiation effect of the recombinant chicken interleukin-6(rChIL-6) on different kinds of vaccines in commercial chicken,rChIL-6 was inoculated by various ways on Newcastle disease virus(NDV) monovalent vaccines,the NDV-chicken infectious bronchitis virus(IBV)-avian influenza virus H9N2 subtype(NDV-IBV-H9) trivalent oil-adjuvant inactivated vaccine,the infectious bursal disease virus(IBDV) oil-adjuvant inactivated vaccine in field test as well as the self-produced NDV monovalent oil-... |
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| Keywords: | chicken recombinant chicken interleukin-6 vaccine immunopotentiation effect Newcastle disease infectious bursal disease avian influenza H9N2 |
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