| 水通道蛋白-4研究进展及法医学意义 |
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| 引用本文： | 王小伟,王英元.水通道蛋白-4研究进展及法医学意义[J].中国法医学杂志,2008,23(2):101-103. |
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| 作者姓名： | 王小伟 王英元 |
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| 作者单位： | 山西医科大学法医学院,山西,太原,030001 |
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| 摘 要： | 头颅创伤、脑卒中、脑肿瘤、缺血性脑损伤、出血性脑损伤均伴有脑水肿的发生，严重者可危及患者生命甚至造成死亡。水通道蛋白-4（Aquaporin-4）作为主要在脑组织中表达的水通道蛋白，起着调节脑内水转运的重要功能，参与脑水肿的病理生理过程，提示研究水通道蛋白-4表达水平可能为法医学外伤性脑损伤时间推断提供新的依据。
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| 关 键 词： | 法医损伤学 水通道蛋白-4 创伤性颅脑损伤 脑水肿 血脑屏障 |
| 文章编号： | 1001-5728(2008)02-0101-03 |
| 修稿时间： | 2007年3月7日 |
Progression of the aquaporin-4 and its potential significance in forensic medicine |
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| WANG Xiao-wei,WANG Ying-yuan.Progression of the aquaporin-4 and its potential significance in forensic medicine[J].Chinese Journal of Forensic Medicine,2008,23(2):101-103. |
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| Authors: | WANG Xiao-wei WANG Ying-yuan |
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| Institution: | ( Shanxi Medical Univercity , School of Forensic Medicine, Taiyuan 030001, China) |
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| Abstract: | Trauma,stroke,brain tumor,ischemic brain injury and bleeding brain damage often associated with brain edema occurred.Patients who suffer those cases may endanger life or even died.Aquaporin-4,as a major expression of aquaporins in brain,plays an important role in regulating water transfer when brain edema.It is suggested that expression of aquparin-4 may provide a new way to estimate the injury time of traumatic brain injury. |
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| Keywords: | Forensic traumatology medicine Aquaporin-4 Traumatic brain injury Brain edema Blood brain barrier |
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