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病毒性心肌炎心肌碱性成纤维生长因子的实验研究
作者姓名:Zha  G
作者单位:中山医科大学法医系法医病理教研室,广东广州510080
基金项目:广东省自然科学基金资助项目!(NO.522- 1500- 203008 )
摘    要:用 8只小鼠接种柯萨奇 B3病毒( Coxsackie B3 viral CVB3),形成病毒性心肌炎动物模型。用免疫组织化学方法对心肌碱性成纤维生长因子( basic Fibroblast Growth Factor:bFGF)的变化进行了研究。目的是观察 CVB3对心肌的损害。结果发现小鼠感染病毒第 3天病变心肌中即有 bFGF阳性表达,并且随病程的延长其阳性程度随之增加。常规 HE染色通常在感染病毒 5天后才出现明显的镜下改变。本研究提示 bFGF可以为病毒性心肌炎早期轻微病变的判定提供帮助。

关 键 词:病毒性心肌炎  成纤维细胞生长因子  免疫组织化学

Experimental study on basic fibroblast growth factors in viral myocarditis
Zha G.Experimental study on basic fibroblast growth factors in viral myocarditis[J].Journal of Forensic Medicine,2000,16(4):210-210,213.
Authors:Zha G
Institution:Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Gungzhou 510080.
Abstract:In order to know earlier pathological changes in myocarditis, 8 rats were inoculated with CVB3, and a model of viral myocarditis was built. The changes of basic fibroblast growth factors (bFGF) in acute viral myocarditis were observed by immunohistochemistry. It was found that the bFGF stain started to show positive at the third day after viral infection and that the positive degree increased afterwards. With normal HE staining, obvious lesion usually appeared under microscopy at least five days after infection. This suggests that the changes of bFGF in myocardium can be used for examination of early and light lesions of viral myocarditis.
Keywords:viral myocarditis  basic fibroblast growth factor  immunohistochemistry  
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