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| 判别函数在同胞鉴定中的应用 | |
| 引用本文： | 陈子翔,王福振,陆惠玲,章雅清.判别函数在同胞鉴定中的应用[J].中国法医学杂志,2012,27(2):129-132. |
| 作者姓名： | 陈子翔 王福振 陆惠玲 章雅清 |
| 作者单位： | 1. 中山大学中山医学院法医物证学教研室,广东广州,510080 2. 吉林市公安局船营分局,吉林 吉林,132011 3. 海南省血液中心,海南海口,570311 |
| 摘 要： | 目的探讨判别函数法在全同胞与半同胞鉴定中的应用价值。方法根据360对全同胞、90对半同胞及360对无关个体的15个STR基因座分型结果,计算全不同(X0)、半相同(X1)和完全相同(X2)的基因座数目,分别根据DFS1=3.898X0+3.973X1-19.481,DHS1=5.687X0+5.300X1-35.112及DR1=7.309X0+5.533X1-44.941的全同胞/半同胞/无关个体判别函数、DFS2=3.872X0+3.931X1-18.895及DR2=7.303X0+5.473X1-44.298全同胞/无关个体判别函数和DHS3=10.227X0+10.436X1-66.102及DR3=11.863X0+11.089X1-79.494半同胞/无关个体判别函数进行判别。结果判别准确率:①用全同胞/半同胞/无关个体判别函数,全同胞组为83.61%,半同胞组为81.11%,无关个体组为83.06%;②用全同胞/无关个体判别函数,全同胞组为96.39%,无关个体组为98.61%;③用半同胞/无关个体判别函数,半同胞组为88.89%,无关个体组为85.00%。结论本文3种判别函数可应用于同胞鉴定,尤其运用全同胞/无关个体判别函数判断同胞关系准确率高,有较高的应用价值。 |
| 关 键 词： | 法医物证学 STR基因座 同胞关系 判别函数分析 等位基因匹配 |
The application of discriminant functions method in full sibling and half sibling identification |
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| Chen Zixiang , Wang Fuzhen , Lu Huiling , Zhang Yaqing.The application of discriminant functions method in full sibling and half sibling identification[J].Chinese Journal of Forensic Medicine,2012,27(2):129-132. | |
| Authors: | Chen Zixiang Wang Fuzhen Lu Huiling Zhang Yaqing |
| Institution: | 1.Department of Forensic Biology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou 510080,China;2.Technical Squadron of Chuanying Branch of Jilin Public Security Bureau,Jilin Jilin 132011,China;3.Hainan Province Blood Center,Haikou 570311,China) |
| Abstract: | Objective To investigate the application of discriminant functions method in full sibling and half sibling identification.Methods 360,90 and 360 pairs of full siblings(FS),half siblings(HS) and unrelated individuals(UR) were genotyped by PowerPlexTM 16 system.The locus numbers of no-allele sharing(X0),halfallele sharing(X1) and two-alleles sharing(X2) were calculated,respectively.The relationship judgments of the investigated full siblings,half siblings or unrelated individuals depended on the calculation results of the discriminant functions published in our previous.Results The accuracy of these discriminant functions ranged from 83.06% to 98.61%,with the highest one in full sibship-unrelated individual groups.Conclusion It is showed that the studied discriminant functions,especially those for full siblings-unrelated individuals,are effective in sibling identification with comparatively high accuracy. |
| Keywords: | forensic biological evidence short tandem repeats sibling relations discriminant analysis allele matching |
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