The use of wildcards in forensic DNA database searches |
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| Institution: | 1. Department of Mathematical Sciences, Aalborg University, Denmark;2. Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;1. Immunological Research, Universy of Cartagena, Cartagena, Colombia;2. Laboratorio GENES Ltda, Medellín, Colombia;3. Instituto de Biología, Universidad de Antioquia, Medellín, Colombia;4. Laboratorio de Genética Molecular, Cruz Roja Ecuatoriana, Quito, Ecuador;5. Universidad Pontificia Bolivariana, Medellín, Colombia;6. IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal;1. Laboratorio de Genética Molecular de Cruz Vital – Cruz Roja Ecuatoriana Quito, Ecuador;2. Laboratorio GENES Ltda, Medellin, Colombia;1. Network of Forensic Science Institutes, Institute of Forensic Medicine, DNA Laboratory, Budapest, Hungary;2. Research Centre for Natural Sciences of the HAS, Department of Complex Systems, Budapest, Hungary |
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| Abstract: | Forensic genetic databases contain millions of DNA profiles worldwide. An allelic drop-out at a heterozygous locus (two different alleles) erroneously results in an observed homozygous profile. To guard against this, wildcards are induced for homozygous profiles. The wildcard represents any allele including the observed allele.In this paper, theoretical expressions for the number of matching loci are derived, results shown from a Danish dataset with more than 50,000 DNA profiles and simulations used to link homozygosity with the drop-out probability, which best mimics wildcard matching. |
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| Keywords: | Forensic genetics DNA database Wildcard Drop-out |
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