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| 微波消解ICP-MS法检测生物检材中汞元素 | |
| 作者姓名： | Ma D Zhang D Zhuo XY Liu W Shen BH Shen M |
| 作者单位： | 1. 复旦大学上海医学院法医学系,上海200032;司法部司法鉴定科学技术研究所上海市法医学重点实验室,上海200063 2. 司法部司法鉴定科学技术研究所上海市法医学重点实验室,上海200063;苏州大学医学部法医学系,江苏苏州215123 3. 司法部司法鉴定科学技术研究所上海市法医学重点实验室,上海,200063 |
| 摘 要： | 目的 建立生物检材中汞的电感耦合等离子体质谱分析方法.方法 采用微波消解法处理样品,以铟(115In)作内标,用电感耦合等离子体质谱仪对血液、尿液和头发中的汞含量进行分析.选择金与汞形成金汞齐,对金消除汞记忆效应的能力进行考察.结果 方法检出限为0.01μg/L,准确度为97.0%～107.1%.检测中添加金质量浓度在... |
| 关 键 词： | 法医毒理学 汞 电感耦合等离子体质谱法 微波消解 |
Determination of Hg in biological samples by inductively coupled plasma mass spectrometry |
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| Ma D,Zhang D,Zhuo XY,Liu W,Shen BH,Shen M.Determination of Hg in biological samples by inductively coupled plasma mass spectrometry[J].Journal of Forensic Medicine,2011,27(3):193-195. | |
| Authors: | Ma Dong Zhang Dan Zhuo Xian-Yi Liu Wei Shen Bao-Hua Shen Min |
| Institution: | MA Dong1,2,ZHANG Dan2,3,ZHUO Xian-yi2,LIU Wei2,SHEN Bao-hua2,SHEN Min2(1.Department of Forensic Medicine,Shanghai Medical College,Fudan University,Shanghai 200032,China,2.Shanghai Key Laboratory of Forensic Medicine,Institute of Forensic Science,Ministry of Justice,P.R.China,Shanghai 200063,3.Department of Forensic Medicine,Medical College of Soochow University,Suzhou 215123,China) |
| Abstract: | Objective To establish an inductively coupled plasma mass spectrometry（ICP-MS） method for determination of Hg in biological samples.Methods The samples were digested with microwave digestion instrument.ICP-MS was applied to detect Hg in blood,urine and hair specimens by using 115In as an internal marker.The ability of gold to eliminate the memory effect of mercury was investigated with the gold amalgamate produced by gold and mercury.Results The limits of detection were in the 0.01 μg/L,and the accuracy of the method ranged from 97.0% to 107.1%.The concentration of gold was 10 μg/L and the memory effect of mercury was resolved.Conclusion The method is accurate,rapid,sensitive and suitable for the cases of mercury poisoning and the clinical diagnosis and monitoring for patients with mercury poisoning. |
| Keywords: | forensic toxicology mercury inductively coupled plasma mass spectrometry microwave digestion |
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