| 闭合性脑损伤后血清和海马的蛋白质表达 |
| |
| 作者姓名： | Shu QM Li ZQ Li LZ Yang SW Zhan L Zhang YL |
| |
| 作者单位： | 武警总医院病理科;武警内蒙古总队医院;武警医学院; |
| |
| 基金项目： | 国家自然科学基金资助项目(30471934) |
| |
| 摘 要： | 目的 研究大鼠脑损伤后血清和海马中蛋白质表达的差异.方法 用雄性SD大鼠制造脑损伤模型,应用弱阳离子交换(WCX2)芯片和铜离子结合(IMAC-Cu)芯片结合表面增强激光解析电离飞行时间质谱技术,分析大鼠闭合性脑损伤后不同时间血清和海马中蛋白质表达谱的变化.结果 WCX2芯片在血清和海马样本中分别捕获436个和364个...
|
| 关 键 词： | 法医遗传学 脑损伤 血清 海马 蛋白质芯片 大鼠 |
Expression of proteins in serum and hippocampus after closed brain injury in rats |
| |
| Shu QM,Li ZQ,Li LZ,Yang SW,Zhan L,Zhang YL.Expression of proteins in serum and hippocampus after closed brain injury in rats[J].Journal of Forensic Medicine,2011,27(2):107-111. |
| |
| Authors: | Shu Qing-ming Li Zhi-qiang Li Ling-zhi Yang Shu-wang Zhan Li Zhang Yong-liang |
| |
| Institution: | SHU Qing-ming1,LI Zhi-qiang2,LI Ling-zhi3,YANG Shu-wang4,ZHAN Li4,ZHANG Yong-liang5(1.Department of Pathology,General Hospital of Chinese People's Armed Police Forces,Beijing 100039,China,2.Inner Mongolian Corps Hospital,Chinese People's Armed Police Forces,Huhhot 010000,3.Medical College of Chinese People's Armed Police Force,Tianjin 300162,China) |
| |
| Abstract: | Objective To explore the difference of expression of proteins between the serum and hippocampus after brain injury in rats.Methods Male SD rats were used to establish brain injury model.The changes of proteins expression profile in serum and hippocampus at different time after brain injury were analyzed using weak cationic exchanger(WCX2) chips and immobilized metal affinity capture arrays-Cu(IMAC-Cu) chips by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.Results A total of 4... |
| |
| Keywords: | forensic genetics brain injury serum hippocampus protein chip rats |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
|
