Antibiotics and probiotics in chronic pouchitis:A comparative proteomic approach |
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| Authors: | Silvia Turroni Beatrice Vitali Marco Candela Paolo Gionchetti Fernando Rizzello Massimo Campieri Patrizia Brigidi |
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| Institution: | Department of Pharmaceutical Sciences University of Bologna Department of Internal Medicine and Gastroenterology Polyclinic S.Orsola |
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| Abstract: | AIM:To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment,using a comparative proteomic approach. METHODS:Two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ ionization-time of flight mass spectrometry were used to characterize the changes related to antibiotic therapy in the protein expression profiles of biopsy samples from patients with chronic refractory pouchitis.The same proteom... |
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| Keywords: | Chronic disease Pouchitis Antibiotics Probiotics Proteins Gene expression |
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