| 重型颅脑损伤视觉听觉P300特征及与智商的相关性 |
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| 引用本文： | 刘子龙,陈凯,刘良,陈晓瑞,饶广勋,李海霞.重型颅脑损伤视觉听觉P300特征及与智商的相关性[J].中国法医学杂志,2009,24(5):304-308. |
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| 作者姓名： | 刘子龙 陈凯 刘良 陈晓瑞 饶广勋 李海霞 |
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| 作者单位： | 1. 华中科技大学同济医学院法医学系,湖北,武汉,430030
2. 华中科技大学同济医学院附属同济医院儿科,湖北,武汉,430030 |
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| 摘 要： | 目的探讨重型颅脑损伤患者视觉和听觉P300的特征及与智商的相关性和其应用价值。方法采用中国修订韦氏成人智力量表与Neuroscan-ERP仪对29名重型颅脑损伤患者（外伤组）和46名健康志愿者（对照组）进行智测及视觉、听觉P300检测,分析其特征和相关性。结果外伤组智商均值明显低于对照组（P〈0.01）;视觉P300包括P2、N2和P3成分,听觉P300包括N1、P2、N2、P3成分。外伤组P300波形分化不良,视觉P300各成分的波幅和潜伏期均较对照组明显降低和延长（P〈0.05）;听觉P300的P2波幅和N2、P3的波幅及潜伏期也明显降低和延长（P〈0.05）。视觉和听觉P300各成分中仅P3潜伏期与总智商呈负相关（r=-0.30-0.42,P〈0.05）。结论重型颅脑损伤患者治疗终结后智能仍明显下降,视觉和听觉P300的波幅和潜伏期亦明显异常,且P3潜伏期与智商呈负相关,可作为评估智能损害的一项神经电生理参考指标。
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| 关 键 词： | 法医临床学 重型颅脑损伤 智商 事件相关电位 视觉听觉刺激 |
The features of visual and auditory P300 and correlations of intelligence quotient in severe traumatic brain injury |
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| LIU Zilong,CHEN Kai,LIU Liang,CHEN Xiaorui,RAO Guangxun,LI Haixia.The features of visual and auditory P300 and correlations of intelligence quotient in severe traumatic brain injury[J].Chinese Journal of Forensic Medicine,2009,24(5):304-308. |
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| Authors: | LIU Zilong CHEN Kai LIU Liang CHEN Xiaorui RAO Guangxun LI Haixia |
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| Institution: | (LIU Zilong1,CHEN Kai1,LIU Liang1,CHEN Xiaorui1,RAO Guangxun1,LI Haixia2 /1.Faculty of Forensic Medicine,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China,2.Department of Pediatrics,Tongji Hospital,Tongji Medical College,China) |
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| Abstract: | Objective To investigate the features of P300 elicited by visual and auditory stimulus,and evaluate the correlations between intelligence quotient and the components of P300 in patients with severe traumatic brain injury(sTBI).Methods P300 values were recorded in 29 patients with intelligence impairment induced by sTBI and in 46 healthy controls while they were asked to performance on visual and auditory Oddball task.Intelligence quotient(IQ) was measured using the Wechsler Adult Intelligence Scale-Revised ... |
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| Keywords: | forensic clinical medicine severe traumatic brain injury intelligence quotient event-related potentials visual and auditory stimulus |
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