| 液压冲击脑损伤后细胞间粘附分子表达的研究 |
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| 作者姓名： | Wang X Li M Liao ZG |
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| 作者单位： | 四川大学华西法医学院病理教研室,四川,成都,610041 |
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| 摘 要： | 目的测定外伤性脑损伤后脑内细胞间粘附分子(ICAM-1)的变化。方法用大鼠液压冲击脑损伤致伤模型制作大鼠脑损伤,伤后2、4、8、12、24h取脑组织,用免疫组织化学方法染色并用MIAS图像分析系统进行图像分析。结果脑损伤后2h即可见ICAM-1在脑内表达上调,12h达高峰,24h已回落。结论测定I-CAM-1在脑内的变化情况,可为推断24h以内脑损伤形成时间及伤后存活时间提供参考。
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| 关 键 词： | 脑损伤 细胞间粘附分子 免疫组织化学 图像分析 |
| 文章编号： | 1004-5619(2002)01-0015-02 |
| 修稿时间： | 2001年6月27日 |
The experimental study of expression of intercellular adhesion molecule-1 after fluid percussion brain injury |
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| Wang X,Li M,Liao ZG.The experimental study of expression of intercellular adhesion molecule-1 after fluid percussion brain injury[J].Journal of Forensic Medicine,2002,18(1):15-16. |
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| Authors: | Wang Xin Li Mei Liao Zhi-gang |
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| Institution: | Department of Forensic Pathology, Sichuan University, West China Forensic Medical College, Chengdu, Sichuan 610041. |
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| Abstract: | Objective To determine the changes of intercellular adhesion molecule-1 after traumatic brain injury. Methods Use the fluid-percussion model to inflict rat brain and take the samples at 2?4?8?12?24 hours after brain injury. The samples were studied by immunohistochemistry method combined with image analysis by MIAS image analysis system. Result The expression of ICAM-1 upregulates at 2 hours, reaches peak at 12 hours and falls down at 24 hours after brain injury. Conclusion The changes of ICAM-1 in brain can provide a backup for estimation of injury time and survival period after brain injury which sustained within 24 hours. |
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| Keywords: | brain injury ICAM-1 immunohistochemistry image analysis |
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