DVC微量注射VIP对大鼠GMBF放大和电针调整效应 |
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作者姓名: | 杨永兴 许冠荪 沈德凯 朱庆丰 刘涌 张道芹 |
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作者单位: | 安徽中医学院针灸经络研究所,安徽合肥230038 |
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基金项目: | 安徽省自然科学基金;97414007; |
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摘 要: | 目的:采用中枢迷走神经背核复合体(DVC)微量注射血管活性肠肽(VIP),观察胃黏膜血流量(GMBF)变化和电针对GMBF的调整作用。方法:采用脑立体定位仪对大鼠中枢进行定位和注射,电针足三里穴,用氢气清除法测定GMBF;放射免疫法测量外周血中VIP含量。结果:DVC微量注射VIP后,血中VIP含量增加(P<0.01),GMBF明显增加(P<0.01)。电针(EA)足三里穴加强了GMBF放大效应。结论:DVC注射VIP对GMBF有放大效应,证实在神经-内分泌-免疫网络系统(NEIS)中VIP是重要的神经肽,DVC是VIP作用的社会中枢特异性部位之一,电针具有协同作用。
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关 键 词: | 迷走神经背核复合体 血管活性肠肽 胃黏膜血流量 电针疗法 |
修稿时间: | 2001/3/26 0:00:00 |
MAGNIFYING EFFECT OF MICRO-INJECTION OFVASOACTIVE INTESTINAL PEPTIDE INTO DORSAL MOTOR NUCLEUSOF VAGUS COMPLEX ON GASTRIC MUCOSA BLOOD FLOW ANDMODULATIONEFFECT OF ELECTRIC ACUPUNCTURE IN RATS |
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Authors: | YANG Yong-xing XU Guan-sun SHEN De-kai ZHU Qing-feng LIU Yong ZHANG Dao-qin |
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Abstract: | Objective:To investigate the changes of gastric mucosal blood flow(GMBF)and regulative effect of electro-acupuncture on GMBF in rats with micro-injection of vasoactive intestinal peptide(VIP) into dorsal motor nucleus of vagus complex(DVC).Method:The neurocentre of rat was located and injected by the stereotaxic apparatus of the rat brain,electro-acupuncture (EA)of Zusanli(ST-36) points was applied.GMBF was measured by the method of hydric gas clearance;The contents of VIP in the serum was assayed by radioimmunoassay.Result:The contents of VIP in the serum,transmucosal potential difference(PD) and GMBF were all increased(P<0.01) after micro-injection of VIP into DVC.These effects were enhanced by EA at Zusanli(ST-36) points.Conclusion:The magnifying effect on GMBF is induced by micro-injection of VIP into DVC,VIP is a strong neuropeptide in nerve endocrine immunity system(NEIS),DVC is a special part of neurocentre influenced by VIP,EA has the synergistic effects on micro-injection of VIP into DVC. |
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Keywords: | Dorsal motor nucleus of vagus complex Vasoactive intestinal peptide Gastric mucosal blood flow Electro-acupuncture Nerve endocrine immunity system |
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