脾虚患者脂质过氧化和红细胞免疫功能关系

目的：探讨脾虚患脂质过氧化对红细胞免疫功能的影响。方法：采用红细胞酵母菌混合花环法和硫代巴比妥酸（TBA）法检测脾虚患红细胞C3b受体花环率（RBC－C3bRR)、血浆及红细胞膜丙二醛（MDA）水平。结果：脾虚患RBC－C3bRR和红细胞胞膜免疫复合物花环率（RBC－ICR）明显降低，血浆MDA和红细胞膜MDA明显升高；RBC－C3bRR与血浆MDA、红细胞膜MDA呈负相关，其中红细胞膜MDA和RBC－C3bRR关系更为密切。结论：红细胞膜脂质过氧化损害对RBC－C3bRR有不利影响。

RELATIONSHIP BETWEEN LIPID PEROXIDATION AND RED BLOOD CELL IMMUNE FUNCTION IN PATIENTS WITH SPLEEN DEFICIENCY

Objective:To explore the effect of lipid peroxidation on red blood cell immune function in patients with spleen deficiency.Method:By the methods of TBA and red blood cell yeast mixed flower circle,the RBC C 3b receptor rate,malonyldialdehyde(MDA) of plasma and erythrocyte membrane in patients with spleen deficiency were determined respectively.Result:The red blood cell C 3b receptor rate(RBC C 3bRR)and red blood cell immune compound(RBC IC) were lowered,but the MDA content in plasma and erythrocyte membrane were increased respectively.The relative analysis suggested that there were relationship between the RBC C 3bRR and MAD content in plasma and erythrocyte membrane.Conclusion:The lipid peroxidation lesion of red blood cell membrane had a bad effect on RBC C 3bRR.