| 正交设计优选黄芩栀子合煎工艺 |
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| 作者姓名： | 黄琪 刘慧 陈建红 吴德玲 顾雪竹 麻印莲 张村 |
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| 作者单位： | 安徽中医药大学药学院,安徽合肥230012;中国中医科学院中药研究所,北京100700;中国中医科学院中药研究所,北京,100700;中国中医科学院中药研究所,北京100700;河南中医学院药学院,河南郑州450008;安徽中医药大学药学院,安徽合肥,230012 |
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| 基金项目： | 国家自然科学基金项目（81173553） |
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| 摘 要： | 目的 正交设计优选黄芩栀子合煎工艺。方法 采用正交试验法，考察加水量、煎煮时间、煎煮次数对黄芩、栀子合煎液中栀子苷含量、黄芩苷含量及干膏得率的影响。结果 优选出的最佳提取工艺为：加8倍量水，提取3次，每次0.5 h。结论 所优选的工艺稳定、合理、可行，可为合理开发含有黄芩、栀子药对的复方制剂提供理论依据。
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| 关 键 词： | 黄芩 栀子 正交试验 提取工艺 |
Optimization of Mixed Decoction Technology for Scutellaria baicalensis and Gardenia jasminoides by Orthogonal Design |
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| Institution: | 1.School of Pharmacy,Anhui University of Chinese Medicine,Anhui Hefei 230012,China;2.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 3.School of Pharmacy,Henan College of Traditional Chinese Medicine,Henan Zhengzhou 450008,China |
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| Abstract: | Objective To optimize the mixed decoction technology for Scutellaria baicalensis and Gardenia jasminoides by orthogonal design. Methods An orthogonal test was performed to investigate the influences of the amount of water, decocting time, and times of decoction on the content of geniposide and baicalin and the yield of dry extract from the mixed decoction solution of Scutellaria baicalensis and Gardenia jasminoides. Results The optimized extraction process was as follows: adding water (8 times), and extracting 3 times (0.5 h each time). Conclusion The optimized process is stable, reasonable, and feasible. This study can provide a theoretical basis for the development of compound preparation of Scutellaria baicalensis and Gardenia jasminoides. |
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| Keywords: | Scutellaria baicalensis Gardenia jasminoides orthogonal test extraction process |
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