加减参苓白术散治疗儿童特应性皮炎脾虚蕴湿证20例

目的 观察加减参苓白术散治疗儿童特应性皮炎脾虚蕴湿证的临床疗效.方法 将40例特应性皮炎脾虚蕴湿证患儿随机分为治疗组和对照组,每组20例.治疗组给予加减参苓白术散及地氯雷他定糖浆口服;对照组仅口服地氯雷他定糖浆.两组均外涂玉泽皮肤屏障修护乳.采用特应性皮炎评分(scoring atopic dermartitis,SCORAD)分别于治疗前,治疗2、4周后对两组患儿的临床症状及体征进行评分,判定临床疗效,并于患儿治疗前和治疗4周后检测外周血嗜酸性粒细胞数(eosinophils,EOS).结果 治疗4周后,两组患儿SCORAD、EOS计数均显著降低(P<0.05),且治疗组SCORAD评分、EOS计数均明显低于对照组(P<0.05).治疗组临床疗效显著优于对照组(P<0.05),治疗组的复发率显著低于对照组(P<0.05).结论 加减参苓白术散治疗儿童特应性皮炎脾虚蕴湿证具有良好疗效,能够改善临床症状.

Clinical Effect of Modified Shenling Baizhu Powder in Treatment of Children with Atopic Dermatitis with Spleen Deficiency and Dampness Accumulation: An Analysis of 20 Cases

Objective To investigate the clinical effect of modified Shenling Baizhu powder in the treatment of children with atopic dermatitis with spleen deficiency and dampness accumulation. Methods A total of 40 patients with atopic dermatitis with spleen deficiency and dampness accumulation were randomly divided into treatment group and control group, with 20 patients in each group. The patients in the treatment group were given oral administration of modified Shenling Baizhu powder combined with desloratadine syrup, and those in the control group were given desloratadine syrup alone; the patients in both groups were given external application of Dr. Yu Skin Barrier Recovery Essence. Scoring atopic dermatitis (SCORAD) was used to determine the scores of clinical symptoms and signs before treatment and at weeks 2 and 4 of treatment and assess clinical outcome, and eosinophils (EOS) were measured before treatment and after 4 weeks of treatment. Results After 4 weeks of treatment, both groups had significant reductions in SCORAD score and EOS count (P<0.05), and the treatment group had significantly lower SCORAD score and EOS count than the control group (P<0.05). Compared with the control group, the treatment group had a significantly better clinical outcome (P<0.05) and a significantly lower recurrence rate (P<0.05). Conclusion Modified Shenling Baizhu powder has a marked clinical effect in the treatment of children with atopic dermatitis with spleen deficiency and dampness accumulation and can improve clinical symptoms.