虎地肠溶胶囊对宫颈癌放射治疗致急性肠损伤的防护作用

目的 探讨虎地肠溶胶囊对宫颈癌患者放射性肠损伤的治疗效果。方法 将54例宫颈癌患者随机分成对照组和观察组，每组27例，对照组予以同步放射治疗和化学治疗，观察组在对照组基础上加用虎地肠溶胶囊；观察两组放射性损伤发生的时间、严重程度；放射治疗前后采用磁共振小肠造影（magnetic resonance enterography, MRE）检查肠损伤程度；采用欧洲癌症研究和治疗组织的30条目生活质量问卷（The European Organization for Research and Treatment of Cancer, Quality of Life Questionnaire Count 30, EORTC QLQ C30）评估两组患者放射性治疗前后生活质量。结果 观察组放射性肠损伤出现时间较对照组显著延迟（P＜0.05）；两组放射性肠损伤分级比较，差异无统计学意义(P＞0.05)；MRE检查结果显示，两组放射治疗后小肠黏膜均明显增厚（P＜0.05），观察组肠黏膜厚度增加程度显著小于对照组（P＜0.05）。EORTC QLQ C30显示虎地肠溶胶囊能够明显改善放射治疗致急性肠损伤的宫颈癌患者的生活质量。结论 虎地肠溶胶囊可有效延缓宫颈癌患者放射治疗后放射性肠损伤的发生，改善放射治疗后肠壁的水肿状态，提高患者生活质量。

Protective Effect of Hudi Enteric coated Capsules Against Acute Intestinal Injury Induced by Radiotherapy for Cervical Cancer

Objective To investigate the clinical effect of Hudi enteric coated capsules in the treatment of radiation induced intestinal injury in patients with cervical cancer. Methods A total of 54 patients with cervical cancer were randomly divided into observation group and control group, with 27 patients in each group. The patients in the control group were given concurrent chemoradiotherapy, and those in the observation group were given Hudi enteric coated capsules in addition to the treatment in the control group. The two groups were compared in terms of onset time and severity of radiation induced intestinal injury. Magnetic resonance enterography (MRE) was performed before and after radiotherapy to evaluate the severity of intestinal injury. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C30) was used to assess quality of life before and after radiotherapy. Results The observation group had a significantly longer time to the onset of radiation induced intestinal injury than the control group (P<0.05). There was no significant difference in the grade of radiation induced intestinal injury between the two groups (P>0.05). MRE showed thickening of the small intestinal mucosa after radiotherapy, which was significantly milder in the observation group than in the control group (P<0.05). EORTC QLQ C30 showed that Hudi enteric coated capsules significantly improved the quality of life of cervical cancer patients with radiation induced intestinal injury. Conclusion In patients with cervical cancer, Hudi enteric coated capsules can effectively delay the onset of radiation induced intestinal injury after radiotherapy, reduce edema of the bowel wall after treatment, and improve quality of life.