通督调神针灸疗法治疗遗忘型轻度认知功能障碍临床观察

目的 观察通督调神针灸疗法对遗忘型轻度认知功能障碍（amnestic mild cognitive impairment，aMCI）患者认知功能的改善作用，探究其部分作用机制。方法 将60例aMCI患者随机分为治疗组和对照组，每组30例。治疗组患者接受通督调神针灸疗法，对照组患者口服尼莫地平，两组疗程均为8周。治疗前后分别采用简易精神状态量表（mini-mental state examination，MMSE）、蒙特利尔认知评估（Montreal cognitive assessment，MoCA）量表和血管性痴呆辨证量表（the syndrome differentiation scale of vascular dementia，SDSVD）评估认知功能，并检测血清超敏C-反应蛋白（high sensitivity C-reactive protein，hs-CRP）和白细胞介素-6（interleukin-6，IL-6）水平。结果 两组治疗后MMSE、MoCA评分均较治疗前显著升高（P<0.05），血清hs-CRP和IL-6水平均较治疗前显著降低（P<0.05），且治疗组治疗后SDSVD评分较治疗前显著降低（P<0.05）。治疗组治疗后MMSE升高值和SDSVD、IL-6降低值均显著大于对照组（P<0.05）。结论 通督调神针灸疗法可明显改善aMCI患者的认知功能，其部分机制与降低血清IL-6有关。

Clinical Effect of Tongdu Tiaoshen Acupuncture in Treatment of Amnestic Mild Cognitive Impairment

Objective To observe the clinical effect of Tongdu Tiaoshen Acupuncture in the treatment of cognitive function in patients with amnestic mild cognitive impairment (aMCI), and to partially investigate its working mechanisms. Methods Sixty patients with aMCI were randomly and equally divided into treatment group and control group. Patients in the treatment group received Tongdu Tiaoshen Acupuncture for 8 weeks, while patients in the control group were orally given nimodipine for 8 weeks. The cognitive function in patients before and after treatment was evaluated using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Syndrome Differentiation Scale of Vascular Dementia (SDSVD). Serum levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were also determined before and after treatment. Results For both groups, the MMSE and MoCA scores were significantly higher after treatment (P<0.05), while serum levels of hs-CRP and IL-6 were significantly lower after treatment (P<0.05). Moreover, the SDSVD score in the treatment group was significantly lower after treatment (P<0.05). Compared with the control group, the treatment group had significantly larger MMSE increase, SDSVD reduction, and IL-6 reduction after treatment (P<0.05). Conclusion Tongdu Tiaoshen Acupuncture can substantially improve cognitive function in patients with aMCI, the partial mechanism for which is associated with serum IL-6 reduction.