| KCNE、KCNQ1与心性猝死的相关性研究进展 |
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| 引用本文： | 李 明,刘 超,黄京璐,郝 博,王小广,刘 宏,盛立会,王怀勇,陈忆九,罗 斌.KCNE、KCNQ1与心性猝死的相关性研究进展[J].中国法医学杂志,2014(1):37-39,43. |
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| 作者姓名： | 李 明 刘 超 黄京璐 郝 博 王小广 刘 宏 盛立会 王怀勇 陈忆九 罗 斌 |
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| 作者单位： | [1]中山大学中山医学院法医学系,广东广州511080 [2]广州市公安局刑事科学技术研究所,广东广州510030 [3]深圳市公安局刑事科学技术研究所,广东深圳518000 [4]司法部司法鉴定科学技术研究所,上海市法医学重点实验室,上海200063 |
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| 基金项目： | 国家自然科学基金（39700167）;国家十二五重大科技攻关项目（2012BAK028002）,上海市法医学重点实验室开放课题（2013KFl307） |
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| 摘 要： | 部分心性猝死由于缺乏明确的病理学改变，其鉴定工作一直是法医工作者的一大难题。近年来，与长QT综合征、心房颤动等致死性心律失常疾病相关基因（KCNE基因家族与KCNQl）等研究逐渐增多。国内外研究发现KCNE和KCNQ1基因编码心肌钾离子通道，其基因异常可引起严重的心律失常，甚至导致心性猝死。因此，死后KCNE和KCNQl的基因检测对于心性猝死鉴定具有重要意义。本文对KCNE、KCNQl与心性猝死的相关性研究进展进行综述，希望能为法医学研究和实践提供参考。
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| 关 键 词： | 法医病理学 长QT综合征 心性猝死 KCNE KCNQ1 |
Research progress between KCNE,KCNQ1 and sudden cardiac death |
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| Li Ming,Liu Chao,Huang Jinglu,Hao Bo,Wang Xiaoguang,Liu Hong,Sheng Lihui,Wang Huaiyong,Chen Yijiu,Luo Bin.Research progress between KCNE,KCNQ1 and sudden cardiac death[J].Chinese Journal of Forensic Medicine,2014(1):37-39,43. |
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| Authors: | Li Ming Liu Chao Huang Jinglu Hao Bo Wang Xiaoguang Liu Hong Sheng Lihui Wang Huaiyong Chen Yijiu Luo Bin |
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| Institution: | 1. Department of Forensic Pathology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China; 2. Guangzhou Institute of Criminal Science and Technology, Guangzhou 510030, China; 3. Shenzhen Institute of Criminal Science and Technology, Shenzhen 518000, China; 4. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice P. R. China, Shanghai 200063, China) |
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| Abstract: | A significant proportion of sudden cardiac death is autopsy-negative even after comprehensive forensic investigation, which is a big problem for forensic experts. In recent years, studies on the genes （ KCNE and KCNQ1 ） which are associated with the fatal arrhythmia such as long QT syndrome and atrial fibrillation have increased gradually. Some studies suggested abnormality in KCNE and KCNQ1 genes encoding potassium ion channels could cause serious arrhythmia, even lead to sudden cardiac death （SCD）. Therefore, the postmortem genetic testing of KCNE and KCNQ1 is of great significance for the appraisal of sudden cardiac death. The resent progress between KCNE ,KCNQ1 and sudden cardiac death was reviewed in this paper, in order to provide the valuable guidance for the forensic research and practice. |
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| Keywords: | forensic pathology long QT syndrome sudden cardiac death KCNE KCNQl |
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