利多卡因在蛛网膜下腔麻醉致死犬体内的分布

目的 观察利多卡因蛛网膜下腔致死犬体内的分布及脊髓液、脊髓与血液中利多卡因含量的比值。方法薄层扫描法检测血、脊髓液、侧脑室液、各节段脊髓和各脏器组织中利多卡因含量。结果 蛛网膜下腔麻醉致死犬脊髓液、各节段脊髓、脑、血液和其它各脏器中利多卡因含量分别为485.6±51.5μg/ml、226.8±35.2-353.8±44.0μg/g、44.9±11.51μg/g、40.3±6.5μg/ml和13.5±13.7-38.0±9.8μg/g。脊髓液与血液中利多卡因含量之比为12.4±2.7,各节段脊髓与血液之比为5.7±0.9-9.0±2.6。结论 蛛网膜下腔麻醉致死犬脊髓液中利多卡因含量最高,脊髓中次之,血液和其它组织中含量较低。脊髓液/血液、脊髓/血液比值平均可达12.4和5.7-9.0。

Distribution of lidocaine in dogs that died of subarachnoid anesthesia

Objective To study the distribution of lidocaine and ratio of lidocaine detected in samples to in dogs killed by subarachnoid anesthesia. Methods After a dose of lidocaine 37.01 mg/kg by a sub-arachnoid space injection, the lidocaine concentration in different organ or tissues of dead dogs was determined by a TLC scanning analysis. Results The lidocaine detected in CSF, spinal cord, brain, blood and other tissues of dogs that died of a lidocaine subarachnoid space injection were 485. 6±51. 5μ,g/ml, 226. 8±35. 2 -353. 8±44.μg/g, 44. 9±11. 5μg/g, 40.3±6. 5μg/ml and 13. 5±13. 7-38. 0±9. 8μg/g. Ratio of lidocaine detected in CSF and spinal cord to in blood were 12. 4 and 5. 7- 9. 0. Conclusion In dogs that died of a lethal lidocaine subarachnoid space injection, lidocaine detected in GSF was the highest , that detected in spinal cord was the second, that detected in blood and other tissues were the lowest. Ratio of lidocaine detected in CSF and spinal cord to in blood were 12.4 and 5. 7 -9. 0.