| DYS448基因座分型缺失分析 |
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| 引用本文： | 郝宏蕾,吴微微,任文彦,苏艳佳,吕德坚.DYS448基因座分型缺失分析[J].中国法医学杂志,2017(4):414-416. |
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| 作者姓名： | 郝宏蕾 吴微微 任文彦 苏艳佳 吕德坚 |
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| 作者单位： | 1. 浙江省公安物证鉴定中心 浙江省刑事科学技术应用研究重点实验室,浙江 杭州,310009;2. 中山大学医学院法医学系,广东 广州,510089 |
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| 摘 要： | 目的调查分析DYS448基因座分型缺失,为法医学提供有意义的数据。方法收集中国汉族5487名无关男性个体血样,其中4479份样本用Y-filerTM试剂盒,1008份样本应用Yfiler PlusTM试剂盒进行复合扩增,所有样本应用AGCU Y-24试剂盒复核;统计DYS448基因座出现基因分型缺失的概率。结果在5487名无关个体的Y-STR数据中,观察到35个个体的35种单倍型中DYS448基因座分型出现缺失,其中2个样本在其它基因座位同时出现多谱带。结论 DYS448基因座分型缺失率为0.637%,在Y-STR数据库与父系鉴定应用中应予以关注。
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| 关 键 词： | 法医物证学 Y-STR DYS448基因座 缺失 |
An analysis of genotypes absence at DYS448 locus |
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| Hao Honglei,Wu Weiwei,Ren Wenyan,Su Yanjia,Lv Dejian.An analysis of genotypes absence at DYS448 locus[J].Chinese Journal of Forensic Medicine,2017(4):414-416. |
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| Authors: | Hao Honglei Wu Weiwei Ren Wenyan Su Yanjia Lv Dejian |
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| Abstract: | Objective To provide the basic data for forensic application by analyzing the genotypes absence at DYS448 locus. Method 5487 bloodstain samples from unrelated male individuals of Chinese Han population were obtained. 4479 samples was co-amplified using Y-filerTM and AGCU Y-24 kits. 1008 samples was co-amplified using Yfiler PlusTM and AGCU Y-24 kits .Probability of genotype absence was calculated. Results 35 samples of 35 haplotypes among 5487 non-related individuals were found to have DYS448 genotypes absence ,while 2 individuals displayed additional alleles at else locus. Conclusion The probability of DYS448 genotype absence was 0.637%, forensic scientists should pay more attention in practical cases and YSTR database. |
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| Keywords: | forensic biological science Y-STR DYS448 locus absence |
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