| 体位性窒息对脑血管损伤的实验观察 |
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| 引用本文： | 竞花兰,陈玉川,李朝晖.体位性窒息对脑血管损伤的实验观察[J].中国法医学杂志,2002,17(3):134-135. |
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| 作者姓名： | 竞花兰 陈玉川 李朝晖 |
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| 作者单位： | 中山大学医学院法医学系,广东,广州,510080 |
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| 摘 要： | 目的 观察体位性窒息对脑血管损伤的影响。方法 家兔20只,致其中10只体位性窒息,另10只断颈处死进行对照。用兔抗人白蛋白抗体和兔抗人(von Willebrand Factor,vWF)抗体进行LSAB免疫组化法显色。结果抗人白蛋白抗体及抗人vWW、检测均显示出阳性;对照组显示不明显。秩和检验显示,两组间具有显著性差异。结论 在体位性窒息时,呼吸障碍所引起的缺氧,可损害脑血管的正常结构。
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| 关 键 词： | 法医病理学 体位性窒息 脑血管损伤 vWF |
| 文章编号： | 1001-5728(2002)03-0134-02 |
| 修稿时间： | 2002年1月1日 |
An experimental study on the cerebral vascular injury in case of positional asphyxia |
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| JING Hualan,CHEN Yuchuan,LI Zhaohui /.An experimental study on the cerebral vascular injury in case of positional asphyxia[J].Chinese Journal of Forensic Medicine,2002,17(3):134-135. |
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| Authors: | JING Hualan CHEN Yuchuan LI Zhaohui / |
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| Institution: | JING Hualan,CHEN Yuchuan,LI Zhaohui /Department of Forensic Pathology,Zhongshan University,Guangzhou 510089 |
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| Abstract: | Objective This research aimed to study if the cerebral vascular injury can be caused by the positional asphyxia. Method The brain tissue sections were studied immunohistochemically (SABC method) by using the anti-human von Willebrand Factor (vWF) and anti-human albumin as the first antibody. Results No positive expression of vWF and albumin was found in the cerebral blood vessels of control group. The vivid positive expression of albumin and vWF were observed in the positional asphyxia group. Conclusion The results indicate that the positional asphyxia can result the expression of the vWF in the cerebral vessels and it seems one of the injury markers in the cerebral blood vessels and can be used to probe the mechanism of positional asphyxia. |
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| Keywords: | Forensic pathology Cerebral vascular injury Positional asphyxia vWF |
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