| 基质金属蛋白酶与心血管疾病及其法医学意义 |
| |
| 引用本文： | 吴薇,冯相平,陈新山.基质金属蛋白酶与心血管疾病及其法医学意义[J].中国法医学杂志,2005,20(1):37-40. |
| |
| 作者姓名： | 吴薇 冯相平 陈新山 |
| |
| 作者单位： | 华中科技大学同济医学院法医病理学教研室,湖北,武汉,430030 |
| |
| 摘 要： | 在心血管疾病发病机制中起重要作用的蛋白质大分子,对于心脏性猝死的发生及确诊具有十分重要的意义。基质金属蛋白酶(Matrixmetalloproteinases,MMPs)是一类锌依赖的金属内肽酶的总称,是降解心肌细胞外基质最重要的蛋白水解酶类。本文就基质金属蛋白酶生物学特性、功能在心血管疾病发生发展中的作用和在法医病理学中的意义作一介绍。
|
| 关 键 词： | 法医病理学 猝死 基质金属蛋白酶 心血管疾病 |
| 文章编号： | 1001-5728(2005)01-0037-04 |
| 修稿时间： | 2003年11月1日 |
Matrix metalloproteinases and cardiovascular disease and its significance in forensic medicine |
| |
| Institution: | (WU Wei,FENG Xiang-ping,CHEN Xin-shanDepartment of Forensic Pathology,Tongji Medical College of Huazhong University of Science and Techology,Wuhan 430030,China) |
| |
| Abstract: | The high molecular protein which plays an important role in the cardiovascular disease has an significance to the happen of sudden cardiac death, and even to its diagnosis. Matrix metalloproteinases (MMPs) are a large family of zinc metallo-en-dopeptidases, which are the most important proteolytic enzymes for the degradation of myocardial extracellular protein. The present review makes a survey of basic biological characteristic, the function and the role of Mmps in cardiovascular disease and its significance to forensic medicine. |
| |
| Keywords: | Forensic pathology Sudden death Matrix metalloproteinases Cardiovascular disease |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
