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| 弥漫性轴索损伤的研究进展 | |
| 引用本文： | 李上勋,刘丹,何光龙,王昊,段祎杰,马祥涛,周亦武.弥漫性轴索损伤的研究进展[J].中国法医学杂志,2010,25(5):338-341. |
| 作者姓名： | 李上勋 刘丹 何光龙 王昊 段祎杰 马祥涛 周亦武 |
| 作者单位： | 1. 华中科技大学同济医学院法医学系,湖北,武汉,430030 2. 华中科技大学同济医学院法医学系,湖北,武汉,430030;武汉科技大学医学院,湖北,武汉,4300653 3. 公安部物证鉴定中心,北京,100038 |
| 基金项目： | 中央级科研院所基本科研业务费面上项目 |
| 摘 要： | 弥漫性轴索损伤（diffuse axonal injury,DAI）以脑白质轴索弥漫性损伤为主要特征,迄今其形成机制尚未完全阐明,不同学科诊断标准迥异,是法医学和神经科学亟待解决的难题。磁共振弥散张量成像（diffusion tensor imaging,DTI）通过检测弥散参数及纤维束成像（fibre tracking,FT）可准确地反映轴索损伤部位及损伤程度,具有广泛的法医学应用前景。本文综述DAI发生机制及诊断方法的研究进展,尤其DTI技术在DAI诊断中的应用。 |
| 关 键 词： | 法医病理学 弥漫性轴索损伤 分子病理学 弥散张量成像 |
Progress of diffuse axonal injury |
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| LI Shangxun,LIU Dan,HE Guanglong,WANG Hao,DUAN Yijie,MA Xiangtao,ZHOU Yiwu.Progress of diffuse axonal injury[J].Chinese Journal of Forensic Medicine,2010,25(5):338-341. | |
| Authors: | LI Shangxun LIU Dan HE Guanglong WANG Hao DUAN Yijie MA Xiangtao ZHOU Yiwu |
| Institution: | 1. Forensic Faculty of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China ; 2. Medical College of Wuhan University of Science and Technology, Wuhan 430065, China; 3. Institute of Frensic Science Ministry of Public Security P. R. C. ,Beijing 100038, China ) |
| Abstract: | Diffuse axonal injury(DAI) is characterized by extensive axonal injury in white matter.So far,the exact mechanism of DAI remained unknown and the diagnostic criteria of that varied in different subjects,contributing to a pressing problem in forensic science and neuroscience.By the means of detecting diffusion parameters and fibre tracking,the sites and extent of axonal injury could be readily determined by diffusion tensor imaging(DTI).This paper thoroughly discussed the progress of DAI in machanism and diagnostic methods,especially for the application of diffusion tensor imaging(DTI) in the diagnosis of DAI. |
| Keywords: | forensic pathology diffuse axonal injury molecular pathology diffusion tensor imaging |
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