| 人类CCK-45C/T遗传多态性及与抑郁症的相关性 |
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| 引用本文： | 张璐,王保捷,丁梅,庞灏,王春红,李春梅,邢佳鑫,宣金锋.人类CCK-45C/T遗传多态性及与抑郁症的相关性[J].中国法医学杂志,2012,27(6):448-450,531. |
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| 作者姓名： | 张璐 王保捷 丁梅 庞灏 王春红 李春梅 邢佳鑫 宣金锋 |
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| 作者单位： | 1. 中国医科大学法医学院,辽宁沈阳110001;中国刑事警察学院法医学系,辽宁沈阳110035
2. 中国医科大学法医学院,辽宁沈阳,110001 |
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| 基金项目： | 辽宁省教育厅高等学校科研项目计划(2004D052) |
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| 摘 要： | 目的 调查胆囊收缩素-45C/T(CCK-45C/T)的遗传多态性,探讨其与抑郁症的遗传相关性.方法 采集111例中国健康汉族人和130例抑郁症患者全血样本,利用TaqMan荧光标记探针杂交技术,使用Prism@7900HT型荧光定量PCR仪,对CCK-45 C/T进行基因频率调查,并比较分析健康人群和抑郁症患病人群CCK-45C/T等位基因的分布差异.结果 CCK-45C/T等位基因T的频率在健康群体中为0.369 4,在抑郁症患者群体中为0.496 2,组间比较存在显著性差异(P＜0.05).结论 CCK-45C/T等位基因T的分布在健康和抑郁症患者中差异显著,该基因可能与抑郁症易感相关.
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| 关 键 词： | 法医物证学 胆囊收缩素 TaqMan探针 多态性 抑郁症 基因 |
Forensic medicine department of Human cholecystokinin gene 45C/T polymorphism and its possible association with depression |
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| Zhang Lu,Wang Baojie,Ding Mei,Pang Hao,Wang Chunhong,Li Chunmei,Xing Jiaxin,Xuan Jinfeng.Forensic medicine department of Human cholecystokinin gene 45C/T polymorphism and its possible association with depression[J].Chinese Journal of Forensic Medicine,2012,27(6):448-450,531. |
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| Authors: | Zhang Lu Wang Baojie Ding Mei Pang Hao Wang Chunhong Li Chunmei Xing Jiaxin Xuan Jinfeng |
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| Institution: | 1/1.China Medical University,Shenyang 110001,China;2.Forensic Medicine Department of China Criminal Police University,Shenyang 100035,China) |
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| Abstract: | Objective To investigate the polymorphism of cholecystokinin gene 45C/T locus(CCK-45C/T)in promoter region and potential association between the polymorphism and depression.Methods We collected the whole blood samples of 111 Chinese healthy Han individuals and 130 individuals with depression,using TaqMan probe labeled with fluorescent dye hybridization technique by ABI Prism7900HT Sequence Detector,to investigate the gene frequency of CCK-45C/T.Results The T allele frequency of CCK-45C/T was 0.496 2 in depressive individuals and 0.369 4 in healthy ones.A significant difference between the two groups was observed(P<0.05).Conclusion There was a significant difference in the T allele frequency of CCK-45C/T between the healthy and depression individuals.It was indicated that the T allele of CCK-45C/T may be a potential susceptibility allele in depression. |
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| Keywords: | forensic biological evidence cholecystokinin TaqMan probe polymorphism depression gene |
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