| GDNF对多巴胺能神经元的保护及治疗MA依赖研究进展 |
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| 引用本文： | 杨璐瑜,洪仕君,苏发丽,刘巨鹏,李利华.GDNF对多巴胺能神经元的保护及治疗MA依赖研究进展[J].中国法医学杂志,2013,28(2):133-136. |
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| 作者姓名： | 杨璐瑜 洪仕君 苏发丽 刘巨鹏 李利华 |
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| 作者单位： | 1. 昆明医科大学法医学院,云南昆明,650500
2. 昆明医科大学科学技术处,云南昆明,650500 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 甲基苯丙胺(MA)的毒性作用与多巴胺系统有密切关系,而大量研究表明胶质细胞源性神经营养因子(GDNF)是一种有效的多巴胺能神经营养因子,本文综述GDNF对多巴胺能神经元保护功能机制及用于治疗MA依赖的研究进展,以期为相关研究和应用提供参考。
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| 关 键 词： | 法医病理学 胶质细胞源性神经营养因子 多巴胺能神经元 甲基苯丙胺 |
Advances in studies on protective effect of GDNF on dopaminergic neurons and its therapeutic effects on MA-dependence |
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| Yang Luyu,Hong Shijun,Su Fali,Liu Jupeng,Li Lihua.Advances in studies on protective effect of GDNF on dopaminergic neurons and its therapeutic effects on MA-dependence[J].Chinese Journal of Forensic Medicine,2013,28(2):133-136. |
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| Authors: | Yang Luyu Hong Shijun Su Fali Liu Jupeng Li Lihua |
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| Institution: | 1.Kunming Medical University School of Forensic Medicine,Kunming 650500,China;2.Science and Technology Department,Kunming Medical University,Kunming 650500,China) |
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| Abstract: | The toxic effects of methamphetamine(MA) and dopamine systems are closely related.A large number of studies have shown that GDNF is an effective dopaminergic neurotrophic factor.In this paper,a variety of physiological functions of GDNF in protecting dopaminergic neurons and progress in studies on its therapeutic effects on MA-dependence are reviewed. |
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| Keywords: | forensic pathology glial cell linederived neurotrophic factor dopaminergic neurons methamphetamine |
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