Measurement of Postmortem 1,5‐anhydroglucitol in Vitreous Humor for Forensic Diagnosis |
| |
| Authors: | Tomoyo Takata PhD Yukie Yamasaki MMS Takashi Kitao PhD Satoru Miyaishi MD PhD |
| |
| Institution: | 1. Department of Medical Technology, Faculty of Health Science, Ehime Prefectural University of Health Sciences, Ehime, Japan;2. Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan |
| |
| Abstract: | In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5‐anhydroglucitol (1,5‐AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5‐AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5‐AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r2 = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5‐AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5‐AG concentration. |
| |
| Keywords: | forensic science postmortem chemistry 1 5‐anhydroglucitol vitreous humor cerebrospinal fluid diabetes mellitus |
|
|
